Investigation published in Antimicrobial Agents and Chemotherapy

September 1^st, 2013

Seven Klebsiella pneumoniae isolated from dogs and cats in Spain were found to be highly resistant to aminoglycosides, and ArmA methyltransferase was responsible for this phenotype. All isolates were typed by MLST as ST11, a human epidemic clone reported worldwide associated among others with OXA-48 and NDM carbapenemases. In the seven strains armA was borne by an IncR plasmid, pB1025, of 50 kb. The isolates were found to co-produce DHA-1 and SHV-11 β-lactamases, as well as QnrB4 resistance determinant. This first report of the ArmA methyltransferase in pets illustrates their importance as a reservoir for human multi-drug resistant K. pneumoniae

Hidalgo L., Gutierrez B., Ovejero CM., Carrilero L., Matrat S., Saba C., Santos-Lopez A., Thomas-Lopez D., Hoefer A., Santurde G., Martin-Espada C. and Gonzalez-Zorn B..

Klebsiella pneumoniae Sequence Type 11 from companion animals bearing ArmA methyltransferase, DHA-1 B-lactamase and QnrB4

Klebsiella pneumoniae Sequence Type 11 from companion animals bearing ArmA methyltransferase, DHA-1 B-lactamase and QnrB4

	Servicio de Zoonosis de Transmisión Alimentaria y Resistencia a Antimicrobianos (ZTA). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).
	Departamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).