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MCR-2-mediated plasmid-borne polymyxin resistance most likely originates from Moraxella pluranimalium

The Journal of Antimicrobial Chemotherapy publish this investigation article

October 1st, 2017

The recent identification of the first plasmid-mediated polymyxin resistance determinants, namely the MCR-1 and MCR-2 enzymes, has constituted an ultimate threat of pandrug resistance in Gram-negative organisms.1–3 These enzymes have been reported only in Enterobacteriaceae, mainly in Escherichia coli and Klebsiella pneumoniae; however, there have been reports from other enterobacterial genera, including Enterobacter, Salmonella and Shigella.1 The mcr-1 and mcr-2 genes have both been identified from cattle and pigs.1–3 In addition, the mcr-1 gene has been identified from chickens,4 but also from river samples and vegetables




Poirel L., Kieffer N., Fernandez-Garayzabal JF., Vela AI., Larpin Y. and Nordmann P.




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MCR-2-mediated plasmid-borne polymyxin resistance most likely originates from Moraxella pluranimalium

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MCR-2-mediated plasmid-borne polymyxin resistance most likely originates from Moraxella pluranimalium



Participants:

Department of Medicine. Faculty of Science. University of Fribourg (UNIFR).

Universidad ComplutenseServicio de Identificación y Caracterización Microbiana (ICM). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

Universidad ComplutenseDepartamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).







The Journal of Antimicrobial Chemotherapy
FACTOR YEAR Q
5.217 2017

NLMID: 7513617

PMID: 29091193

ISSN: 0305-7453



TITLE: MCR-2-mediated plasmid-borne polymyxin resistance most likely originates from Moraxella pluranimalium


JOURNAL: J. Antimicrob. Chemother.


NUMERACIÓN: 72(10):2947-2949


AÑO: 2017


PUBLISHER: Oxford University Press


AUTHORS: Poirel L., Kieffer N., Fernandez-Garayzabal JF., Vela AI., Larpin Y. and Nordmann P.


VISAVET PARTICIPANTS


3rd
José Francisco Fernández-Garayzabal Fernández
4th
Ana Isabel Vela Alonso

DOI: https://doi.org/10.1093/jac/dkx225


CITE THIS PUBLICATION:

Poirel L., Kieffer N., Fernandez-Garayzabal JF., Vela AI., Larpin Y. and Nordmann P. MCR-2-mediated plasmid-borne polymyxin resistance most likely originates from Moraxella pluranimalium. The Journal of Antimicrobial Chemotherapy. 72(10):2947-2949. 2017. (A). ISSN: 0305-7453. DOI: 10.1093/jac/dkx225


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