Investigation published in Antimicrobial Agents and Chemotherapy

September 1^st, 2012

TEM-1 is the dominat β-lactamase of Haemophilus influenzae and can be located on small plasmids. Three distinct plasmids from 4,304 to 5,646 nt were characterized: pA1606, pA1209 and pPN223. In addition to TEM-1 and a replication enzyme of the Rep 3 superfamily, pA1606 encodes a Tn3 resolvase gene and pA1606 and pA1209 encode an ORF similar to a plasmid recombination enzyme gene described in Gram-positive bacteria. The plasmids transformed strain Rd to the ampicillin-resistant phenotype.

Søndergaard A., San Millan A., Santos-Lopez A., Nielsen SM., Gonzalez-Zorn B. and Norskov-Lauritsen N.

Molecular organization of small plasmids bearing blaTEM-1 and conferring resistance to beta-lactams in Haemophilus influenzae

Molecular organization of small plasmids bearing blaTEM-1 and conferring resistance to beta-lactams in Haemophilus influenzae

	Servicio de Zoonosis de Transmisión Alimentaria y Resistencia a Antimicrobianos (ZTA). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).
	Departamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).
	Department of Clinical Microbiology. Aarhus University Hospital (AUH).