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Molecular organization of small plasmids bearing blaTEM-1 and conferring resistance to beta-lactams in Haemophilus influenzae

Investigation published in Antimicrobial Agents and Chemotherapy

September 1st, 2012

TEM-1 is the dominat β-lactamase of Haemophilus influenzae and can be located on small plasmids. Three distinct plasmids from 4,304 to 5,646 nt were characterized: pA1606, pA1209 and pPN223. In addition to TEM-1 and a replication enzyme of the Rep 3 superfamily, pA1606 encodes a Tn3 resolvase gene and pA1606 and pA1209 encode an ORF similar to a plasmid recombination enzyme gene described in Gram-positive bacteria. The plasmids transformed strain Rd to the ampicillin-resistant phenotype.




Søndergaard A., San Millan A., Santos-Lopez A., Nielsen SM., Gonzalez-Zorn B. and Norskov-Lauritsen N.




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Molecular organization of small plasmids bearing blaTEM-1 and conferring resistance to beta-lactams in Haemophilus influenzae

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Molecular organization of small plasmids bearing blaTEM-1 and conferring resistance to beta-lactams in Haemophilus influenzae



Participants:

Universidad ComplutenseServicio de Zoonosis de Transmisión Alimentaria y Resistencia a Antimicrobianos (ZTA). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

Universidad ComplutenseDepartamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).

Aarhus University HospitalDepartment of Clinical Microbiology. Aarhus University Hospital (AUH).







Antimicrobial Agents and Chemotherapy
FACTOR YEAR Q
4.565 2012

NLMID: 315061

PMID: 22733069

ISSN: 0066-4804



TITLE: Molecular organization of small plasmids bearing blaTEM-1 and conferring resistance to beta-lactams in Haemophilus influenzae


JOURNAL: Antimicrob. Agents Chemother.


NUMERACIÓN: 56(9):4958-60


AÑO: 2012


PUBLISHER: American Society for Microbiology


AUTHORS: Søndergaard A., San Millan A., Santos-Lopez A., Nielsen SM., Gonzalez-Zorn B. and Norskov-Lauritsen N.


VISAVET PARTICIPANTS


Bruno González Zorn

DOI: https://doi.org/10.1128/AAC.00408-12


CITE THIS PUBLICATION:

Søndergaard A., San Millan A., Santos-Lopez A., Nielsen SM., Gonzalez-Zorn B. and Norskov-Lauritsen N. Molecular organization of small plasmids bearing blaTEM-1 and conferring resistance to beta-lactams in Haemophilus influenzae. Antimicrobial Agents and Chemotherapy. 56(9):4958-60. 2012. (A). ISSN: 0066-4804. DOI: 10.1128/AAC.00408-12


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