Home \ Outreach \ Outreach articles \


Multicopy plasmids allow bacteria to escape from fitness trade-offs during evolutionary innovation

Nature Ecology & Evolution publish this article

May 1st, 2018

Rodriguez Beltran J., Hernandez Beltran JCR., de la Fuente J., Escudero JA., Fuentres Hernandez A., Craig MacLean R., Pena Miller R. and San Millan A.


Understanding the mechanisms governing innovation is a central element of evolutionary theory. Novel traits usually arise through mutations in existing genes, but trade-offs between new and ancestral protein functions are pervasive and constrain the evolution of innovation. Classical models posit that evolutionary innovation circumvents the constraints imposed by trade-offs through genetic amplifications, which provide functional redundancy. Bacterial multicopy plasmids provide a paradigmatic example of genetic amplification, yet their role in evolutionary innovation remains largely unexplored. Here, we reconstructed the evolution of a new trait encoded in a multicopy plasmid using TEM-1 β-lactamase as a model system. Through a combination of theory and experimentation, we show that multicopy plasmids promote the coexistence of ancestral and novel traits for dozens of generations, allowing bacteria to escape the evolutionary constraints imposed by trade-offs. Our results suggest that multicopy plasmids are excellent platforms for evolutionary innovation, contributing to explain their extreme abundance in bacteria




See this article
Multicopy plasmids allow bacteria to escape from fitness trade-offs during evolutionary innovation

Related link: Multicopy plasmids allow bacteria to escape from fitness trade-offs during evolutionary innovation

Participants:

Comunidad de MadridServicio de Microbiología. Hospital Universitario Ramón y Cajal. Salud Madrid. Comunidad de Madrid. 111

Comunidad de MadridInstituto Ramón y Cajal de Investigación Sanitaria (IRYCIS). Universidad Complutense (UCM). Universidad Autónoma de Madrid (UAM). Universidad de Alcalá (UAH). Salud Madrid. Comunidad de Madrid. 111

Universidad Nacional Autónoma de MéxicoCentro de Ciencias Genómicas. Universidad Nacional Autónoma de México (UNAM). 111

Universidad ComplutenseServicio de Zoonosis de Transmisión Alimentaria y Resistencia a Antimicrobianos (ZTA). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM). 111

Universidad ComplutenseDepartamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM). 111

University of OxfordDepartment of Zoology. University of Oxford. 111

Instituto de Salud Carlos IIICentro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP). Instituto de Salud Carlos III (ISCIII). 111








TITLE: Multicopy plasmids allow bacteria to escape from fitness trade-offs during evolutionary innovation


TYPE: Article


AUTHORS: Rodriguez Beltran J., Hernandez Beltran JCR., de la Fuente J., Escudero JA., Fuentres Hernandez A., Craig MacLean R., Pena Miller R. and San Millan A.


VISAVET PARTICIPANTS


José Antonio Escudero García-Calderón

JOURNAL: Nature Ecology & Evolution


LANGUAJE: Spanish


NUMERATION: 2(5):873-881


DATE: May 1st, 2018


PUBLISHING COMPANY: Macmillan Publishers Limited


DOI: https://doi.org/ 10.1038/s41559-018-0529-z


CITE THIS PUBLICATION:

Rodriguez Beltran J., Hernandez Beltran JCR., de la Fuente J., Escudero JA., Fuentres Hernandez A., Craig MacLean R., Pena Miller R. and San Millan A. Multicopy plasmids allow bacteria to escape from fitness trade-offs during evolutionary innovation.. Nature Ecology & Evolution. 2(5):873-881. Macmillan Publishers Limited. 2018. (Article)


UNITS: