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Phylodynamics and evolutionary epidemiology of African swine fever p72-CVR genes in Eurasia and Africa

Investigation article published in PLoS ONE

February 28th, 2018

African swine fever (ASF) is a complex infectious disease of swine that constitutes devastating impacts on animal health and the world economy. Here, we investigated the evolutionary epidemiology of ASF virus (ASFV) in Eurasia and Africa using the concatenated gene sequences of the viral protein 72 and the central variable region of isolates collected between 1960 and 2015. We used Bayesian phylodynamic models to reconstruct the evolutionary history of the virus, to identify virus population demographics and to quantify dispersal patterns between host species. Results suggest that ASFV exhibited a significantly high evolutionary rate and population growth through time since its divergence in the 18th century from East Africa, with no signs of decline till recent years. This increase corresponds to the growing pig trade activities between continents during the 19th century, and may be attributed to an evolutionary drift that resulted from either continuous circulation or maintenance of the virus within Africa and Eurasia. Furthermore, results implicate wild suids as the ancestral host species (root state posterior probability = 0.87) for ASFV in the early 1700s in Africa. Moreover, results indicate the transmission cycle between wild suids and pigs is an important cycle for ASFV spread and maintenance in pig populations, while ticks are an important natural reservoir that can facilitate ASFV spread and maintenance in wild swine populations. We illustrated the prospects of phylodynamic methods in improving risk-based surveillance, support of effective animal health policies, and epidemic preparedness in countries at high risk of ASFV incursion




Alkhamis MA., Gallardo C., Jurado C., Soler A., Arias M. and Sanchez-Vizcaino JM..




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Phylodynamics and evolutionary epidemiology of African swine fever p72-CVR genes in Eurasia and Africa

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Phylodynamics and evolutionary epidemiology of African swine fever p72-CVR genes in Eurasia and Africa


Participants:

Kuwait Institute For Scientific Research (KISR).

University of MinnesotaDepartment of Veterinary Population Medicine. College of Veterinary Medicine. University of Minnesota (UMM).

Instituto Nacional de Investigación y Tecnología Agraria y AlimentariaEuropean Union Reference Laboratory for African Swine Fever. Centro de Investigación en Sanidad Animal (CISA). Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA).

Universidad ComplutenseServicio de Inmunología Viral y Medicina Preventiva (SUAT). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

Universidad ComplutenseDepartamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).







PLoS ONE
FACTOR YEAR Q
2.776 2018

NLMID: 101285081

PMID: 29489860

ISSN: 1932-6203



TITLE: Phylodynamics and evolutionary epidemiology of African swine fever p72-CVR genes in Eurasia and Africa


JOURNAL: PLoS ONE


NUMERACIÓN: 13(2):e0192565


AÑO: 2018


PUBLISHER: Public Library Science


AUTHORS: Alkhamis MA., Gallardo C., Jurado C., Soler A., Arias M. and Sanchez-Vizcaino JM..


VISAVET PARTICIPANTS


José Manuel Sánchez-Vizcaíno Rodríguez

DOI: https://doi.org/ 10.1371/journal.pone.0192565


CITE THIS PUBLICATION:

Alkhamis MA., Gallardo C., Jurado C., Soler A., Arias M. and Sanchez-Vizcaino JM. Phylodynamics and evolutionary epidemiology of African swine fever p72-CVR genes in Eurasia and Africa. PLoS ONE. 13(2):e0192565. 2018. (A). ISSN: 1932-6203. DOI: 10.1371/journal.pone.0192565


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