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Plasmid containing CpG motifs enhances the efficacy of porcine reproductive and respiratory syndrome live attenuated vaccine

Veterinary Immunology and Immunopathology publish this investigation article

December 1st, 2011

Porcine reproductive and respiratory syndrome (PRRS) is now among the most important swine diseases that affect the Chinese swine industry. Both killed and live attenuated vaccines are currently used against the disease, but neither of them could provide full protection after vaccination. In the present study, the adjuvanticity of a plasmid containing CpG motifs (pUC18-CpG) was introduced to enhance the efficacy of a commercial PRRS live attenuated vaccine. After vaccination, PRRSV-specific antibodies, PRRSV-specific cytokines, and clinical parameters were studied and compared between different vaccinated groups. During a following challenge study, co-administration of pUC18-CpG with the vaccine could confer higher protection rate. Our results have shown that co-administration of pUC18-CpG with the vaccine could elicit more potent adaptive immune response and provide better protection




Guo X., Zhang Q., Hou S., Zhai G., Zhu H. and Sanchez-Vizcaino JM..




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Plasmid containing CpG motifs enhances the efficacy of porcine reproductive and respiratory syndrome live attenuated vaccine

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Plasmid containing CpG motifs enhances the efficacy of porcine reproductive and respiratory syndrome live attenuated vaccine


Participants:

Universidad ComplutenseServicio de Inmunología Viral y Medicina Preventiva (SUAT). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

Universidad ComplutenseDepartamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).

Institute of Animal Science (IAS). Chinese Academy of Agricultural Sciences (CAAS).

Yangzhou UniversityCollege of Veterinary Medicine. Yangzhou University (YZU).







Veterinary Immunology and Immunopathology
FACTOR YEAR Q
2.076 2011

NLMID: 8002006

PMID: 21917319

ISSN: 0165-2427



TITLE: Plasmid containing CpG motifs enhances the efficacy of porcine reproductive and respiratory syndrome live attenuated vaccine


JOURNAL: Vet. Immunol. Immunopathol.


NUMERACIÓN: 144(3-4):405-9


AÑO: 2011


PUBLISHER: Elsevier Scientific


AUTHORS: Guo X., Zhang Q., Hou S., Zhai G., Zhu H. and Sanchez-Vizcaino JM..


VISAVET PARTICIPANTS


José Manuel Sánchez-Vizcaíno Rodríguez

DOI: https://doi.org/ 10.1016/j.vetimm.2011.07.023


CITE THIS PUBLICATION:

Guo X., Zhang Q., Hou S., Zhai G., Zhu H. and Sanchez-Vizcaino JM. Plasmid containing CpG motifs enhances the efficacy of porcine reproductive and respiratory syndrome live attenuated vaccine. Veterinary Immunology and Immunopathology. 144(3-4):405-9. 2011. (A). ISSN: 0165-2427. DOI: 10.1016/j.vetimm.2011.07.023


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