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Polymyxin resistance caused by mgrB inactivation is not associated with significant biological cost in Klebsiella pneumoniae

Investigation article published in Antimicrobial Agents and Chemotherapy

May 1st, 2015

Inactivation of the mgrB gene, encoding a negative feed-back regulator of the PhoPQ signaling system, was recently shown to be a common mutational mechanism responsible for acquired polymyxin resistance among carbapenemase-producing Klebsiella pneumoniae from clinical sources. In this work we show that mgrB mutants can easily be selected in vitro from different K. pneumoniae lineages, and that mgrB inactivation is not associated with a significant biological cost




Cannatelli A., Santos-Lopez A., Giani T., Gonzalez-Zorn B. and Rossolini GM.




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Polymyxin resistance caused by mgrB inactivation is not associated with significant biological cost in Klebsiella pneumoniae

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Polymyxin resistance caused by mgrB inactivation is not associated with significant biological cost in Klebsiella pneumoniae



Participants:

Universidad ComplutenseDepartamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).

Universidad ComplutenseServicio de Zoonosis de Transmisión Alimentaria y Resistencia a Antimicrobianos (ZTA). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

Università degli Studi di Siena (UNISI).

Dipartimento di Medicina Sperimentale e Clinica. Università degli Studi di Firenze (UNIFI).

Clinical Microbiology and Virology Unit. Careggi University Hospital.







Antimicrobial Agents and Chemotherapy
FACTOR YEAR Q
4.415 2015

NLMID: 315061

PMID: 25691629

ISSN: 0066-4804



TITLE: Polymyxin resistance caused by mgrB inactivation is not associated with significant biological cost in Klebsiella pneumoniae


JOURNAL: Antimicrob. Agents Chemother.


NUMERACIÓN: 59(5):2898-900


AÑO: 2015


PUBLISHER: American Society for Microbiology


AUTHORS: Cannatelli A., Santos-Lopez A., Giani T., Gonzalez-Zorn B. and Rossolini GM.


VISAVET PARTICIPANTS


Bruno González Zorn

DOI: https://doi.org/10.1128/AAC.04998-14


CITE THIS PUBLICATION:

Cannatelli A., Santos-Lopez A., Giani T., Gonzalez-Zorn B. and Rossolini GM. Polymyxin resistance caused by mgrB inactivation is not associated with significant biological cost in Klebsiella pneumoniae. Antimicrobial Agents and Chemotherapy. 59(5):2898-900. 2015. (A). ISSN: 0066-4804. DOI: 10.1128/AAC.04998-14


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