Investigation article published in Antimicrobial Agents and Chemotherapy

May 1^st, 2015

Inactivation of the mgrB gene, encoding a negative feed-back regulator of the PhoPQ signaling system, was recently shown to be a common mutational mechanism responsible for acquired polymyxin resistance among carbapenemase-producing Klebsiella pneumoniae from clinical sources. In this work we show that mgrB mutants can easily be selected in vitro from different K. pneumoniae lineages, and that mgrB inactivation is not associated with a significant biological cost

Cannatelli A., Santos-Lopez A., Giani T., Gonzalez-Zorn B. and Rossolini GM.

Polymyxin resistance caused by mgrB inactivation is not associated with significant biological cost in Klebsiella pneumoniae

Polymyxin resistance caused by mgrB inactivation is not associated with significant biological cost in Klebsiella pneumoniae

	Departamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).
	Servicio de Zoonosis de Transmisión Alimentaria y Resistencia a Antimicrobianos (ZTA). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).
	Università degli Studi di Siena (UNISI).
	Dipartimento di Medicina Sperimentale e Clinica. Università degli Studi di Firenze (UNIFI).
	Clinical Microbiology and Virology Unit. Careggi University Hospital.