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Safety of African Swine Fever Vaccine Candidate Lv17/WB/Rie1 in Wild Boar: Overdose and Repeated Doses

Investigation article published in Frontiers in immunology

November 30th, 2021

African swine fever (ASF) is a highly lethal infectious disease that affects domestic pigs and wild boar. Outbreaks of ASF have grown considerably in the last decade causing important economic consequences for the swine industry. Its control is hampered by the lack of an effective treatment or vaccine. In Europe, the wild boar is a key wild reservoir for ASF. The results of the oral vaccination trial of wild boar with Lv17/WB/Rie1 are hope for this problem. However, this vaccine candidate has certain safety concerns, since it is a naturally attenuated vaccine. Therefore, the current study aims to evaluate the safety of this vaccine candidate in terms of overdose (high dose) and repeated doses (revaccination) in wild boar. Low-dose orally vaccinated animals developed only a slight transient fever after vaccination and revaccination. This was also the case for most of the high-dose vaccinated wild boar, except for one of them which succumbed after revaccination. Although this fatality was related to hierarchical fights between animals, we consider that further studies are required for clarification. Considering these new results and the current epidemiological situation of ASF in wild boar, this vaccine prototype is a promising tool for the control of the disease in these wild populations, although further studies are needed




Barasona JA., Cadenas-Fernández E., Kosowska A., Barroso-Arevalo S., Rivera B., Sanchez R., Porras-Gonzalez N., Gallardo C. and Sanchez-Vizcaino JM..




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Safety of African Swine Fever Vaccine Candidate Lv17/WB/Rie1 in Wild Boar: Overdose and Repeated Doses

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Safety of African Swine Fever Vaccine Candidate Lv17/WB/Rie1 in Wild Boar: Overdose and Repeated Doses



Participants:

Universidad ComplutenseServicio de Inmunología Viral y Medicina Preventiva (SUAT). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

Universidad ComplutenseDepartamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).

Instituto Nacional de Investigación y Tecnología Agraria y AlimentariaEuropean Union Reference Laboratory for African Swine Fever. Centro de Investigación en Sanidad Animal (CISA). Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA).

Consejo Superior de Investigaciones CientíficasConsejo Superior de Investigaciones Científicas (CSIC).







Frontiers in immunology
FACTOR YEAR Q
7.561 2020

NLMID: 101530960

PMID: 34917082

ISSN: 1664-3224



TITLE: Safety of African Swine Fever Vaccine Candidate Lv17/WB/Rie1 in Wild Boar: Overdose and Repeated Doses


JOURNAL: Front Immunol


NUMERACIÓN: 12:761753


AÑO: 2021


PUBLISHER: Frontiers Research Foundation


AUTHORS: Barasona JA., Cadenas-Fernández E., Kosowska A., Barroso-Arevalo S., Rivera B., Sanchez R., Porras-Gonzalez N., Gallardo C. and Sanchez-Vizcaino JM..


VISAVET PARTICIPANTS


First
José Ángel Barasona García-Arévalo
2nd
Estefanía Cadenas Fernández
3rd
Aleksandra Kosowska
4th
Sandra Barroso Arévalo
5th
Belén Rivera Arroyo
7th
Néstor Porras González
Last
José Manuel Sánchez-Vizcaíno Rodríguez

DOI: https://doi.org/10.3389/fimmu.2021.761753


CITE THIS PUBLICATION:

Barasona JA., Cadenas-Fernández E., Kosowska A., Barroso-Arevalo S., Rivera B., Sanchez R., Porras-Gonzalez N., Gallardo C. and Sanchez-Vizcaino JM. Safety of African Swine Fever Vaccine Candidate Lv17/WB/Rie1 in Wild Boar: Overdose and Repeated Doses. Frontiers in immunology. 12:761753. 2021. (A). ISSN: 1664-3224. DOI: 10.3389/fimmu.2021.761753


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