Salmonella Typhimurium infection primes a nutriprive mechanism in piglets
Investigation article published in Veterinary Microbiology
April 15th, 2016
Salmonella enterica serovar Typhimurium (S. Typhimurium) is an important cause of acute food- borne zoonoses worldwide, typically carried by pigs. It is well known that Salmonella has evolved a wide array of strategies enabling it to invade the host, but little information is available on the specific host responses to Salmonella infections. In the present study, we used an in vivo approach (involving piglets infected with a virulent or an attenuated S. Typhimurium strain) coupled to histological and proteomic analysis of the cecum mucosa, to highlight the host pathways activated during S. Typhimurium infection. We confirm the complex host-pathogen interaction. Our data showed that the metabolic and the cytoskeleton organization functions were the most significantly altered. In particular, the modifications of energy metabolic pathway could suggest a "nutriprive" mechanism, in which the host reduce its metabolic and energetic status to limit Salmonella infection. This study could represent a preliminary approach, providing information useful to better understand the host-Salmonella interaction
Miarelli M., Drumo R., Signorelli F., Marchitelli C., Pavone S., Pesciarioli M., Ruggeri J., Chirullo B., Ammendola S., Battistoni A., Alborali GL., Manuali E. and Pasquali P.
| Consiglio per la ricerca in agricoltura e l´analisi dell´economia agrari (CREA). | |
 | Department of Veterinary Public Health and Food Safety. Istituto Superiore di Sanità. |
| Department of Comparative Biomedicine and Food Science (BCA). Università degli Studi di Padova (UNIPD). | |
| Istituto Zooprofilattico Sperimentale dell’Umbria e delle Marche (IZSUM). | |
 | Servicio de Zoonosis de Transmisión Alimentaria y Resistencia a Antimicrobianos (ZTA). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM). |
| Department of Veterinary Diagnostic. Istituto Zooprofilattico Sperimentale della Lombardia e dell Emilia Romagna (IZSLER). | |
| Department of Biology. Università degli Studi di Roma Tor Vergata. | |
