Investigation article published in Antimicrobial Agents and Chemotherapy

July 1^st, 2013

Streptococcus suis is an emerging zoonotic agent responsible for high-mortality outbreaks among the human population in China. In this species, the ABC transporter SatAB mediates fluoroquinolone resistance when overexpressed. Here we describe and characterize satR, an ORF encoding a MarR-superfamily regulator that acts as a repressor of satAB. satR is cotranscribed with satAB and its interruption entails the overexpression of the pump, leading to a clinically-relevant increase in resistance to fluoroquinolones

Escudero JA., San Millan A., Montero N., Gutierrez B., Ovejero CM., Carrilero L. and Gonzalez-Zorn B..

SatR is a repressor of fluoroquinolone efflux pump SatAB

SatR is a repressor of fluoroquinolone efflux pump SatAB

	Servicio de Zoonosis de Transmisión Alimentaria y Resistencia a Antimicrobianos (ZTA). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).
	Departamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).