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Systematic Determination of Herpesvirus in Free-Ranging Cetaceans Stranded in the Western Mediterranean: Tissue Tropism and Associated Lesions

Investigation article published in Viruses-Basel

October 28th, 2021

The monitoring of herpesvirus infection provides useful information when assessing marine mammals’ health. This paper shows the prevalence of herpesvirus infection (80.85%) in 47 cetaceans stranded on the coast of the Valencian Community, Spain. Of the 966 tissues evaluated, 121 tested positive when employing nested-PCR (12.53%). The largest proportion of herpesvirus-positive tissue samples was in the reproductive system, nervous system, and tegument. Herpesvirus was more prevalent in females, juveniles, and calves. More than half the DNA PCR positive tissues contained herpesvirus RNA, indicating the presence of actively replicating virus. This RNA was most frequently found in neonates. Fourteen unique sequences were identified. Most amplified sequences belonged to the Gammaherpesvirinae subfamily, but a greater variation was found in Alphaherpesvirinae sequences. This is the first report of systematic herpesvirus DNA and RNA determination in free-ranging cetaceans. Nine (19.14%) were infected with cetacean morbillivirus and all of them (100%) were coinfected with herpesvirus. Lesions similar to those caused by herpesvirus in other species were observed, mainly in the skin, upper digestive tract, genitalia, and central nervous system. Other lesions were also attributable to concomitant etiologies or were nonspecific. It is necessary to investigate the possible role of herpesvirus infection in those cases




Vargas-Castro I., Melero M., Crespo JL., Jimenez MA., Sierra E., Rubio-Guerri C., Arbelo M., Fernandez A., Garcia-Parraga D. and Sanchez-Vizcaino JM..




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Systematic Determination of Herpesvirus in Free-Ranging Cetaceans Stranded in the Western Mediterranean: Tissue Tropism and Associated Lesions

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Systematic Determination of Herpesvirus in Free-Ranging Cetaceans Stranded in the Western Mediterranean: Tissue Tropism and Associated Lesions



Participants:

Universidad ComplutenseServicio de Inmunología Viral y Medicina Preventiva (SUAT). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

Universidad ComplutenseDepartamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).

Comunidad de MadridConsejería de Sanidad. Comunidad de Madrid.

Generalitat ValencianaOceanogràfic. Ciudad de las Artes y las Ciencias. Generalitat Valenciana.

Universidad ComplutenseDepartamento de Medicina y Cirugía Animal. Facultad de Veterinaria. Universidad Complutense (UCM).

Universidad de Las Palmas de Gran CanariaInstituto Universitario de Sanidad Animal y Seguridad Alimentaria (IUSA). Facultad de Veterinaria. Universidad de Las Palmas de Gran Canaria (ULPGC).

Universidad CEU Cardenal HerreraUniversidad CEU Cardenal Herrera (CEU-UCH).







Viruses-Basel
FACTOR YEAR Q
5.048 2020

NLMID: 101509722

PMID: 34834986

ISSN: 1999-4915



TITLE: Systematic Determination of Herpesvirus in Free-Ranging Cetaceans Stranded in the Western Mediterranean: Tissue Tropism and Associated Lesions


JOURNAL: Viruses


NUMERACIÓN: 13(11)


AÑO: 2021


PUBLISHER: MDPI


AUTHORS: Vargas-Castro I., Melero M., Crespo JL., Jimenez MA., Sierra E., Rubio-Guerri C., Arbelo M., Fernandez A., Garcia-Parraga D. and Sanchez-Vizcaino JM..


VISAVET PARTICIPANTS


First
Ignacio Vargas Castro
2nd
Mar Melero Asensio
Last
José Manuel Sánchez-Vizcaíno Rodríguez

DOI: https://doi.org/10.3390/v13112180


CITE THIS PUBLICATION:

Vargas-Castro I., Melero M., Crespo JL., Jimenez MA., Sierra E., Rubio-Guerri C., Arbelo M., Fernandez A., Garcia-Parraga D. and Sanchez-Vizcaino JM. Systematic Determination of Herpesvirus in Free-Ranging Cetaceans Stranded in the Western Mediterranean: Tissue Tropism and Associated Lesions. Viruses-Basel. 13(11). 2021. (A). ISSN: 1999-4915. DOI: 10.3390/v13112180


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