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The study of the adjuvanticity of plasmid containing swine-specific CpG motif on two swine vaccines

Guo Xiaoyu defended the PhD Thesis at the Faculty of Veterinary Medicine of the Complutense University of Madrid

July 22nd, 2013

CpG motif is described as a type of Immunostimulatory Sequence (ISS),in which an unmethylated cytosine-phosphate-guanosine (CpG) motif is flanked by two 5′ purines and two 3′ pyrimidines. Since its discovery in 1995, several studies have shown that ODNs containing unmethylated CpG motifs (designated as CpG ODN) can activate host immune defense mechanisms, leading to both innate and acquired immune responses through toll-like receptor 9 (TLR9)–mediated recognition





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The study of the adjuvanticity of plasmid containing swine-specific CpG motif on two swine vaccines


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Guo Xiaoyu

TITLE: The study of the adjuvanticity of plasmid containing swine-specific CpG motif on two swine vaccines


TYPE: PhD Thesis


AUTHOR: Guo Xiaoyu


DIRECTORS: Hongfei Z. and Sanchez-Vizcaino JM.


DATE: July 22nd, 2013


LANGUAGE: English



CITE THIS PUBLICATION:

Guo Xiaoyu. The study of the adjuvanticity of plasmid containing swine-specific CpG motif on two swine vaccines. Universidad Complutense de Madrid. July 22nd, 2013. (PhD Thesis)


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