The study of the adjuvanticity of plasmid containing swine-specific CpG motif on two swine vaccines
Guo Xiaoyu defended the PhD Thesis at the Faculty of Veterinary Medicine of the Complutense University of Madrid
July 22nd, 2013
CpG motif is described as a type of Immunostimulatory Sequence (ISS)，in which an unmethylated cytosine-phosphate-guanosine (CpG) motif is flanked by two 5′ purines and two 3′ pyrimidines. Since its discovery in 1995, several studies have shown that ODNs containing unmethylated CpG motifs (designated as CpG ODN) can activate host immune defense mechanisms, leading to both innate and acquired immune responses through toll-like receptor 9 (TLR9)–mediated recognition
