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Tuberculosis epidemiology in islands: insularity, hosts and trade

Investigation article published in PLoS ONE

July 29th, 2013

Because of their relative simplicity and the barriers to gene flow, islands are ideal systems to study the distribution of biodiversity. However, the knowledge that can be extracted from this peculiar ecosystem regarding epidemiology of economically relevant diseases has not been widely addressed. We used information available in the scientific literature for 10 old world islands or archipelagos and original data on Sicily to gain new insights into the epidemiology of the Mycobacterium tuberculosis complex (MTC). We explored three nonexclusive working hypotheses on the processes modulating bovine tuberculosis (bTB) herd prevalence in cattle and MTC strain diversity: insularity, hosts and trade. Results suggest that bTB herd prevalence was positively correlated with island size, the presence of wild hosts, and the number of imported cattle, but neither with isolation nor with cattle density. MTC strain diversity was positively related with cattle bTB prevalence, presence of wild hosts and the number of imported cattle, but not with island size, isolation, and cattle density. The three most common spoligotype patterns coincided between Sicily and mainland Italy. However in Sicily, these common patterns showed a clearer dominance than on the Italian mainland, and seven of 19 patterns (37%) found in Sicily had not been reported from continental Italy. Strain patterns were not spatially clustered in Sicily. We were able to infer several aspects of MTC epidemiology and control in islands and thus in fragmented host and pathogen populations. Our results point out the relevance of the intensity of the cattle commercial networks in the epidemiology of MTC, and suggest that eradication will prove more difficult with increasing size of the island and its environmental complexity, mainly in terms of the diversity of suitable domestic and wild MTC hosts




Acevedo P., Romero B., Vicente J., Caracappa S., Galluzzo P., Marineo S., Vicari D., Torina A., Casal C., de la Fuente J. and Gortazar C.




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Tuberculosis epidemiology in islands: insularity, hosts and trade

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Tuberculosis epidemiology in islands: insularity, hosts and trade


Participants:

Universidad ComplutenseServicio de Micobacterias (MYC). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

Generalitat de CatalunyaInstituto de Investigación y Tecnología Agroalimentarias (IRTA). Generalitat de Catalunya.

Gobierno de Castilla-La ManchaSanidad y Biotecnología (SaBio). Instituto de Investigación en Recursos Cinegéticos (IREC). Consejo Superior de Investigaciones Científicas (CSIC). Universidad de Castilla La Mancha (UCLM). Gobierno de Castilla-La Mancha (JCCM).

Universidade do PortoCentro de Investigação em Biodiversidade e Recursos Genétivos (CIBIO). Universidade do Porto (UP).

Istituto Zooprofilattico Sperimentale della SiciliaIstituto Zooprofilattico Sperimentale della Sicilia (IZSSI).

Oklahoma State UniversityDepartament of Veterinary Pathobiology. Center for Veterinary Health Sciences (CVHS). Oklahoma State University (OSU).







PLoS ONE
FACTOR YEAR Q
3.534 2013

NLMID: 101285081

PMID: 23923053

ISSN: 1932-6203



TITLE: Tuberculosis epidemiology in islands: insularity, hosts and trade


JOURNAL: PLoS ONE


NUMERACIÓN: 8(7):e71074


AÑO: 2013


PUBLISHER: Public Library Science


AUTHORS: Acevedo P., Romero B., Vicente J., Caracappa S., Galluzzo P., Marineo S., Vicari D., Torina A., Casal C., de la Fuente J. and Gortazar C.


VISAVET PARTICIPANTS


Beatriz Romero Martínez

DOI: https://doi.org/ 10.1371/journal.pone.0071074


CITE THIS PUBLICATION:

Acevedo P., Romero B., Vicente J., Caracappa S., Galluzzo P., Marineo S., Vicari D., Torina A., Casal C., de la Fuente J. and Gortazar C. Tuberculosis epidemiology in islands: insularity, hosts and trade. PLoS ONE. 8(7):e71074. 2013. (A). ISSN: 1932-6203. DOI: 10.1371/journal.pone.0071074


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