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Unmasking subtle differences in the infectivity of microevolved Mycobacterium tuberculosis variants coinfecting the same patient

Investigation article published in International Journal of Medical Microbiology

December 1st, 2013

Clonal variants of Mycobacterium tuberculosis can emerge as a result of microevolution phenomena. The functional significance of these subtle genetic rearrangements is normally disregarded. We show that clonal variants from two patients had different infective behaviours in some in vitro cellular infection models but not in others. Microevolution may have a subtle impact on infectivity, but specific experimental conditions are needed to unmask it




Navarro Y., Perez-Lago L., Sislema F., Herranz M., de Juan L., Bouza E. and Garcia de Viedma D.




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Unmasking subtle differences in the infectivity of microevolved Mycobacterium tuberculosis variants coinfecting the same patient

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Unmasking subtle differences in the infectivity of microevolved Mycobacterium tuberculosis variants coinfecting the same patient



Participants:

Universidad ComplutenseServicio de Micobacterias (MYC). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

Universidad ComplutenseDepartamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).

CEI Campus MoncloaCEI Campus Moncloa.

Instituto de Salud Carlos IIICentro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES). Instituto de Salud Carlos III (ISCIII).

Universidad ComplutenseFacultad de Medicina. Universidad Complutense (UCM).

Comunidad de MadridInstituto de Investigación Sanitaria Gregorio Marañón (IISGM). Servicio de Microbiología y Enfermedades Infecciosas. Hospital General Universitario Gregorio Marañón. Consejería de Sanidad. Comunidad de Madrid.







FACTOR YEAR Q
3.420 2013 2º

NLMID: 100898849

PMID: 24183098

ISSN: 1438-4221



TITLE: Unmasking subtle differences in the infectivity of microevolved Mycobacterium tuberculosis variants coinfecting the same patient


JOURNAL: Int J Med Microbiol


NUMERACIÓN: 303(8):693-6


AÑO: 2013


PUBLISHER: Urban & Fischer Verlag


AUTHORS: Navarro Y., Perez-Lago L., Sislema F., Herranz M., de Juan L., Bouza E. and Garcia de Viedma D.


Lucía de Juan Ferré

DOI: https://doi.org/10.1016/j.ijmm.2013.10.002


CITE THIS PUBLICATION:

Navarro Y., Perez-Lago L., Sislema F., Herranz M., de Juan L., Bouza E. and Garcia de Viedma D. Unmasking subtle differences in the infectivity of microevolved Mycobacterium tuberculosis variants coinfecting the same patient. International Journal of Medical Microbiology. 303(8):693-6. 2013. (A). ISSN: 1438-4221. DOI: 10.1016/j.ijmm.2013.10.002


UNITS:

Servicio de Micobacterias (MYC)
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