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Characterization of genetic differences between Mycobacterium avium subsp. paratuberculosis type I and type II isolates

Investigación publicada en Journal of Clinical Microbiology

1 de noviembre de 2003

A combination of representational difference analysis and comparative DNA sequencing revealed that four type I (sheep) isolates of Mycobacterium avium subsp. paratuberculosis were differentiated from nine type II (bovine) isolates by the presence of an 11-bp insertion in a novel M. avium subsp. paratuberculosis-specific region of genomic DNA. Further, our studies show that M. avium subsp. paratuberculosis type I isolates contain three type-specific loci that are missing in M. avium subsp. paratuberculosis type II but are present in M. avium subsp. avium. Taken together, the results are consistent with the hypothesis that M. avium subsp. paratuberculosis type I strains are an evolutionary intermediate between M. avium subsp. avium and M. avium subsp. paratuberculosis type II isolates or share a subset of M. avium subsp. avium type-specific loci through horizontal transfer




Dohmann K., Strommenger B., Stevenson K., de Juan L., Stratmann J., Kapur V., Bull TJ. y Gerlach GF.




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Characterization of genetic differences between Mycobacterium avium subsp. paratuberculosis type I and type II isolates

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Characterization of genetic differences between Mycobacterium avium subsp. paratuberculosis type I and type II isolates



Participantes:

Universidad ComplutenseDepartamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).

Institut für Mikrobiologie. Tierärztliche Hochschule Hannover.

Moredun Research Institute.

St George´s University of London (SGUL).

University of MinnesotaBioMedical Genomics Center. University of Minnesota (UMM).

Universidad ComplutenseServicio de Micobacterias (MYC). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).







Journal of Clinical Microbiology
FACTOR YEAR Q
3.489 2003

NLMID: 7505564

PMID: 14605167

ISSN: 0095-1137



TÍTULO: Characterization of genetic differences between Mycobacterium avium subsp. paratuberculosis type I and type II isolates


REVISTA: J Clin Microbiol


NUMERACIÓN: 41(11):5215-23


AÑO: 2003


EDITORIAL: American Society for Microbiology


AUTORES: Dohmann K., Strommenger B., Stevenson K., de Juan L., Stratmann J., Kapur V., Bull TJ. and Gerlach GF.


Lucía de Juan Ferré

DOI: https://doi.org/10.1128/JCM.41.11.5215-5223.2003...


CITA ESTA PUBLICACIÓN:

Dohmann K., Strommenger B., Stevenson K., de Juan L., Stratmann J., Kapur V., Bull TJ. y Gerlach GF. Characterization of genetic differences between Mycobacterium avium subsp. paratuberculosis type I and type II isolates. Journal of Clinical Microbiology. 41(11):5215-23. 2003. (A). ISSN: 0095-1137. DOI: 10.1128/JCM.41.11.5215-5223.2003


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