Investigación publicada en Animals

17 de enero de 2023

Chronic inflammatory enteropathies are the most common cause of chronic vomiting and diarrhea in dogs. The pathogenesis of this disease is known to be multifactorial, where intestinal barrier dysfunction, immunological dysregulation and gut microbiota changes play a central role. Most sequencing studies assessing the intestinal microbiota in canine species have been made to evaluate fecal samples. Therefore, in this study, we aimed to characterize the intestinal bacterial microbiota from duodenal biopsies and fecal samples in dogs with inflammatory bowel disease at the diagnosis time and to compare it to healthy dogs. Our study results demonstrate that
dogs with inflammatory bowel disease have significantly different gut microbiota when compared to healthy control dogs, but these changes are more obvious in the fecal microbiota rather than in the duodenal mucosal-associated one. Further investigations including functionality approaches targeting the gut microbiome at both levels are warranted

Diaz-Reganon D., Garcia-Sancho M., Villaescusa A., Sainz A., Agulla B., Reyes-Prieto M., Rodriguez-Bertos A. y Rodriguez-Franco F.

Characterization of the Fecal and Mucosa-Associated Microbiota in Dogs with Chronic Inflammatory Enteropathy

Characterization of the Fecal and Mucosa-Associated Microbiota in Dogs with Chronic Inflammatory Enteropathy

	Departamento de Medicina y Cirugía Animal. Facultad de Veterinaria. Universidad Complutense (UCM).
	Department Medicina i Cirurgia Animals. Facultat de Veterinària. Universitat Autònoma de Barcelona (UAB).
	Sequencing and Bioinformatics Service. Foundation for the Promotion of Sanitary and Biomedical Research.
	Servicio de Patología y Veterinaria Forense (SAP). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).