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Comparative genomics and evolutionary analysis of Lactococcus garvieae isolated from human endocarditis

Investigación publicada en Microbial Genomics

1 de febrero de 2022

Lactococcus garvieae is a well-known pathogen of fish, but is rarely involved in infections in humans and other mammals. In humans, the main clinical manifestation of L. garvieae infections is endocarditis usually related to the ingestion of contaminated food, such as undercooked fish and shellfish. This study presents the first complete genomic sequence of a clinical L. garvieae strain isolated from a patient with endocarditis and its comparative analysis with other genomes. This human isolate contains a circular chromosome of 2 099 060 bp and one plasmid of 50 557 bp. In comparison with other fully sequenced L. garvieae strains, the chromosomal DNA of L. garvieae Lg-Granada carries a low proportion of insertion sequence elements and a higher number of putative prophages. Our results show that, in general, L. garvieae is a highly recombinogenic species with an open pangenome in which almost 30 % of its genome has undergone horizontal transfers. Within the genus Lactococcus, L. lactis is the main donor of genetic components to L. garvieae but, taking Lg-Granada as a representative, this bacterium tends to import more genes from Bacilli taxa than from other Lactococcus species




Frances-Cuesta C., Ansari I., Fernandez-Garayzabal JF., Gibello A. y Gonzalez-Candelas F.




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Comparative genomics and evolutionary analysis of Lactococcus garvieae isolated from human endocarditis

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Comparative genomics and evolutionary analysis of Lactococcus garvieae isolated from human endocarditis



Participantes:

Universitat de ValènciaUnidad Mixta y Genómica y Salud Pública. Fundació per al Foment de la Investigació Sanitària i Biomèdica (FISABIO). Universitat de València (UV).

Centros de Investigación Biomédica en Red de Epidemiologia y Salud Publica ((CIBER-ESP)).

Universidad ComplutenseDepartamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).

Universidad ComplutenseServicio de Identificación y Caracterización Microbiana (ICM). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).







Microbial Genomics
FACTOR YEAR Q
4.868 2021

PMID: 35196218

ISSN: 257-5858



TÍTULO: Comparative genomics and evolutionary analysis of Lactococcus garvieae isolated from human endocarditis


REVISTA: Microb. Genomics


NUMERACIÓN: 8(2):000771


AÑO: 2022


EDITORIAL: Microbiology Society


AUTORES: Frances-Cuesta C., Ansari I., Fernandez-Garayzabal JF., Gibello A. and Gonzalez-Candelas F.


PARTICIPANTES VISAVET


José Francisco Fernández-Garayzabal Fernández

DOI: https://doi.org/10.1099/mgen.0.000771


CITA ESTA PUBLICACIÓN:

Frances-Cuesta C., Ansari I., Fernandez-Garayzabal JF., Gibello A. y Gonzalez-Candelas F. Comparative genomics and evolutionary analysis of Lactococcus garvieae isolated from human endocarditis. Microbial Genomics. 8(2):000771. 2022. (A). ISSN: 257-5858. DOI: 10.1099/mgen.0.000771


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