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Genomic and Pathogenic Investigations of Streptococcus suis Serotype 7 Population derived from a Human Patient and Pigs

Investigación publicada en Emerging microbes and infections

11 de octubre de 2021

Streptococcus suis is one of the important emerging zoonotic pathogens. Serotype 2 is most prevalent in patients worldwide. In the present study, we first isolated one S. suis serotype 7 strain GX69 from the blood culture of a patient with septicemia complicated with pneumonia in China. In order to deepen the understanding of S. suis serotype 7 population characteristics, we investigated the phylogenetic structure, genomic features, and virulence of S. suis serotype 7 population, including 35 strains and 79 genomes. Significant diversities were revealed in S. suis serotype 7 population, which were clustered into 22 sequence types (STs), five minimum core genome (MCG) groups, and six lineages. Lineages 1, 3a, and 6 were mainly constituted by genomes from Asia. Genomes of Lineages 2, 3b, and 5a were mainly from Northern America. Most of genomes from Europe (41/48) were clustered into Lineage 5b. In addition to strain GX69, 13 of 21 S. suis serotype 7 representative strains were classified as virulent strains using the C57BL/6 mouse model. Virulence-associated genes preferentially present in highly pathogenic S. suis serotype 2 strains were not suitable as virulence indicators for S. suis serotype 7 strains. Integrative mobilizable elements were widespread and may play a critical role in disseminating antibiotic resistance genes of S. suis serotype 7 strains. Our study confirmed S. suis serotype 7 is a non-negligible pathotype and deepened the understanding of the population structure of S. suis serotype 7, which provided valuable information for the improved surveillance of this serotype




Liang P., Wang M., Gottschalk M., Vela AI., Estrada AA., Wang J., Du P., Luo M., Wu Z. y Zheng H.




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Genomic and Pathogenic Investigations of Streptococcus suis Serotype 7 Population derived from a Human Patient and Pigs

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Genomic and Pathogenic Investigations of Streptococcus suis Serotype 7 Population derived from a Human Patient and Pigs


Participantes:

Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases. National Institute for Communicable Disease Control and Prevention. Chinese Center for Disease Control and Prevention (CDC).

Guangxi Zhuang Autonomous Region Center for Disease Prevention and Control.

Centre de Recherche en Infectiologie Porcine (CRIP). Faculté de Médicine Vétérinaire. Université de Montréal (UM).

Universidad ComplutenseServicio de Identificación y Caracterización Microbiana (ICM). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

Universidad ComplutenseDepartamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).

University of MinnesotaCollege of Veterinary Medicine. University of Minnesota (UMM).

Institute of Infectious Diseases. Beijing Ditan Hospital. Capital Medical University.

Yulin Center for Disease Prevention and Control.

MOE Joint International Research Laboratory of Animal Health and Food Safety. College of Veterinary Medicine. Nanjing Agricultural University.







Emerging microbes and infections
FACTOR YEAR Q
1.163 2020

NLMID: 101594885

PMID: 34635002

ISSN: 2222-1751



TÍTULO: Genomic and Pathogenic Investigations of Streptococcus suis Serotype 7 Population derived from a Human Patient and Pigs


REVISTA: Emerg Microbes Infect


NUMERACIÓN: 1-41


AÑO: 2021


EDITORIAL: TAYLOR & FRANCIS LTD


AUTORES: Liang P., Wang M., Gottschalk M., Vela AI., Estrada AA., Wang J., Du P., Luo M., Wu Z. and Zheng H.


PARTICIPANTES VISAVET


Ana Isabel Vela Alonso

DOI: https://doi.org/10.1080/22221751.2021.1988725


CITA ESTA PUBLICACIÓN:

Liang P., Wang M., Gottschalk M., Vela AI., Estrada AA., Wang J., Du P., Luo M., Wu Z. y Zheng H. Genomic and Pathogenic Investigations of Streptococcus suis Serotype 7 Population derived from a Human Patient and Pigs. Emerging microbes and infections. 1-41. 2021. (A). ISSN: 2222-1751. DOI: 10.1080/22221751.2021.1988725


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