Inicio \ Investigación \ Publicaciones científicas \


Global Distribution of Extended Spectrum Cephalosporin and Carbapenem Resistance and Associated Resistance Markers in Escherichia coli of Swine Origin - A Systematic Review and Meta-Analysis

Investigación publicada en Frontiers in Microbiology

10 de mayo de 2022

Third generation cephalosporins and carbapenems are considered critically important antimicrobials in human medicine. Food animals such as swine can act as reservoirs of antimicrobial resistance (AMR) genes/bacteria resistant to these antimicrobial classes, and potential dissemination of AMR genes or resistant bacteria from pigs to humans is an ongoing public health threat. The objectives of this systematic review and meta-analysis were to: (1) estimate global proportion and animal-level prevalence of swine E. coli phenotypically resistant to third generation cephalosporins (3GCs) and carbapenems at a country level; and (2) measure abundances and global distribution of the genetic mechanisms that confer resistance to these antimicrobial classes in these E. coli isolates. Articles from four databases (CAB Abstracts, PubMed/MEDLINE, PubAg, and Web of Science) were screened to extract relevant data. Overall, proportion of E. coli resistant to 3GCs was lower in Australia, Europe, and North America compared to Asian countries. Globally, <5% of all E. coli were carbapenem-resistant. Fecal carriage rates (animal-level prevalence) were consistently manifold higher as compared to pooled proportion of resistance in E. coli isolates. blaCTX–M were the most common 3GC resistance genes globally, with the exception of North America where blaCMY were the predominant 3GC resistance genes. There was not a single dominant blaCTX–M gene subtype globally and several blaCTX–M subtypes were dominant depending on the continent. A wide variety of carbapenem-resistance genes (blaNDM–, VIM–, IMP–, OXA–48, and KPC–) were identified to be circulating in pig populations globally, albeit at very-low frequencies. However, great statistical heterogeneity and a critical lack of metadata hinders the true estimation of prevalence of phenotypic and genotypic resistance to these antimicrobials. Comparatively frequent occurrence of 3GC resistance and emergence of carbapenem resistance in certain countries underline the urgent need for improved AMR surveillance in swine production systems in these countries




Singh-Hayer S., Casanova-Higes A., Paladino E., Elnekave E., Nault A., Johnson T., Bender J., Perez A. y Alvarez J..




Ver artículo
Global Distribution of Extended Spectrum Cephalosporin and Carbapenem Resistance and Associated Resistance Markers in Escherichia coli of Swine Origin - A Systematic Review and Meta-Analysis





Participantes:

University of MinnesotaDepartment of Veterinary Population Medicine. College of Veterinary Medicine. University of Minnesota (UMM).

Department of Biology. University of Nebraska at Omaha.

Universidad de ZaragozaDepartamento de Patología Animal. Facultad de Veterinaria. Universidad de Zaragoza (UNIZAR).

Hebrew University of JerusalemThe Robert H. Smith Faculty of Agriculture. Food and Environment Sciences. Hebrew University of Jerusalem.

University of MinnesotaHealth Science Libraries. University of Minnesota (UMM).

University of MinnesotaDepartment of Veterinary and Biomedical Sciences. College of Veterinary Medicine. University of Minnesota (UMM).

University of MinnesotaSchool of Public Health. University of Minnesota (UMM).

Universidad ComplutenseCentro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

Universidad ComplutenseDepartamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).







Frontiers in Microbiology
FACTOR YEAR Q
5.640 2020

NLMID: 101548977

ISSN: 1664-302X



TÍTULO: Global Distribution of Extended Spectrum Cephalosporin and Carbapenem Resistance and Associated Resistance Markers in Escherichia coli of Swine Origin - A Systematic Review and Meta-Analysis


REVISTA: Front Microbiol


NUMERACIÓN: 13:853810


AÑO: 2022


EDITORIAL: Frontiers Research Foundation


AUTORES: Singh-Hayer S., Casanova-Higes A., Paladino E., Elnekave E., Nault A., Johnson T., Bender J., Perez A. and Alvarez J..


PARTICIPANTES VISAVET


Julio Álvarez Sánchez

DOI: https://doi.org/10.3389/fmicb.2022.853810


CITA ESTA PUBLICACIÓN:

Singh-Hayer S., Casanova-Higes A., Paladino E., Elnekave E., Nault A., Johnson T., Bender J., Perez A. y Alvarez J. Global Distribution of Extended Spectrum Cephalosporin and Carbapenem Resistance and Associated Resistance Markers in Escherichia coli of Swine Origin - A Systematic Review and Meta-Analysis. Frontiers in Microbiology. 13:853810. 2022. (A). ISSN: 1664-302X. DOI: 10.3389/fmicb.2022.853810