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Globetrotting strangles: the unbridled national and international transmission of Streptococcus equi between horses

Investigación publicada en Microbial Genomics

8 de marzo de 2021

The equine disease strangles, which is characterized by the formation of abscesses in the lymph nodes of the head and neck, is one of the most frequently diagnosed infectious diseases of horses around the world. The causal agent, Streptococcus equi subspecies equi , establishes a persistent infection in approximately 10 % of animals that recover from the acute disease. Such ‘carrier’ animals appear healthy and are rarely identified during routine veterinary examinations pre-purchase or transit, but can transmit S. equi to naïve animals initiating new episodes of disease. Here, we report the analysis and visualization of phylogenomic and epidemiological data for 670 isolates of S. equi recovered from 19 different countries using a new core-genome multilocus sequence typing (cgMLST) web bioresource. Genetic relationships among all 670 S. equi isolates were determined at high resolution, revealing national and international transmission events that drive this endemic disease in horse populations throughout the world. Our data argue for the recognition of the international importance of strangles by the Office International des Épizooties to highlight the health, welfare and economic cost of this disease. The Pathogenwatch cgMLST web bioresource described herein is available for tailored genomic analysis of populations of S. equi and its close relative S. equi subspecies zooepidemicus that are recovered from horses and other animals, including humans, throughout the world. This article contains data hosted by Microreact




Mitchell C., Steward KF., Charbonneau ARL., Walsh S., Wilson H., Timoney JF., Wernery U., Joseph M., Craig D., van Maanen K., Hoogkamer-van Gennep A., Leon A., Witkowski L., Rzewuska M., Stefanska I., Zychska M., van Loon G., Cursons R., Patty O., Acke E., Gilkerson JR., El-Hage C., Allen J., Bannai H., Kinoshita Y., Niwa H., Becu T., Pringle J., Guss B., Bose R., Abbott Y., Katz L., Leggett B., Buckley TC., Blum SE., Cruz F., Fernadez-Ros A., Marotti Campi MC., Preziuso S., Robinson C., Newton JR., Schofield E., Brooke B., Boursnell M., de Brauwere N., Kirton R., Barton CK., Abudahab K., Taylor B., Yeats CA., Goater R., Aanensen DM., Harris SR., Parkhill J., Holden MTG. y Waller AS.




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Globetrotting strangles: the unbridled national and international transmission of Streptococcus equi between horses

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Globetrotting strangles: the unbridled national and international transmission of Streptococcus equi between horses


Participantes:

Animal Health TrustAnimal Health Trust (AHT).

Gluk Equine Research Center.

Central Veterinary Research Laboratory.

Emirates Racing Authority.

Animal Health Service.

Labéo Frank Duncombe.

Institute of Veterinary Medicine. Warsaw University of Life Sciences – SGGW, Warsaw.

University of GhentUniversity of Ghent (UGENT).

University of Waikato.

Massey University.

University of MelbourneUniversity of Melbourne.

Japan Racing Association.

Clinica Equina.

Department of Biomedical Sciences and Veterinary Public Health. Swedish University of Agricultural Sciences (SLU).

Labor Dr Böse GmbH.

University College DublinUniversity College Dublin (UCD).

Irish Equine Centre.

Kimron Veterinary Institute (KVI).

Universidad ComplutenseServicio de Vigilancia Sanitaria Equina (SEVISEQ). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

Laboratorio ExopolLaboratorio Exopol.

Al Khalediah Equine Hospital.

Università degli Studi di Camerino.

Redwings Horse Sanctuary.

Weatherford Equine Medical Centre.

University of OxfordLi Ka Shing Centre for Health Information and Discovery. Nuffield Department of Medicine. University of Oxford.

Wellcome Trust Sanger InstituteCentre for Genomic Pathogen Surveillance. Wellcome Trust Sanger Institute.

University of CambridgeUniversity of Cambridge.

University of St Andrews.

Intervacc AB.







Microbial Genomics
FACTOR YEAR Q
5.237 2020

PMID: 33684029

ISSN: 257-5858



TÍTULO: Globetrotting strangles: the unbridled national and international transmission of Streptococcus equi between horses


REVISTA: Microb. Genomics


AÑO: 2021


EDITORIAL: Microbiology Society


AUTORES: Mitchell C., Steward KF., Charbonneau ARL., Walsh S., Wilson H., Timoney JF., Wernery U., Joseph M., Craig D., van Maanen K., Hoogkamer-van Gennep A., Leon A., Witkowski L., Rzewuska M., Stefanska I., Zychska M., van Loon G., Cursons R., Patty O., Acke E., Gilkerson JR., El-Hage C., Allen J., Bannai H., Kinoshita Y., Niwa H., Becu T., Pringle J., Guss B., Bose R., Abbott Y., Katz L., Leggett B., Buckley TC., Blum SE., Cruz F., Fernadez-Ros A., Marotti Campi MC., Preziuso S., Robinson C., Newton JR., Schofield E., Brooke B., Boursnell M., de Brauwere N., Kirton R., Barton CK., Abudahab K., Taylor B., Yeats CA., Goater R., Aanensen DM., Harris SR., Parkhill J., Holden MTG. and Waller AS.


PARTICIPANTES VISAVET


Fátima Cruz López

DOI: https://doi.org/10.1099/mgen.0.000528


CITA ESTA PUBLICACIÓN:

Mitchell C., Steward KF., Charbonneau ARL., Walsh S., Wilson H., Timoney JF., Wernery U., Joseph M., Craig D., van Maanen K., Hoogkamer-van Gennep A., Leon A., Witkowski L., Rzewuska M., Stefanska I., Zychska M., van Loon G., Cursons R., Patty O., Acke E., Gilkerson JR., El-Hage C., Allen J., Bannai H., Kinoshita Y., Niwa H., Becu T., Pringle J., Guss B., Bose R., Abbott Y., Katz L., Leggett B., Buckley TC., Blum SE., Cruz F., Fernadez-Ros A., Marotti Campi MC., Preziuso S., Robinson C., Newton JR., Schofield E., Brooke B., Boursnell M., de Brauwere N., Kirton R., Barton CK., Abudahab K., Taylor B., Yeats CA., Goater R., Aanensen DM., Harris SR., Parkhill J., Holden MTG. y Waller AS. Globetrotting strangles: the unbridled national and international transmission of Streptococcus equi between horses. Microbial Genomics. 2021. (A). ISSN: 257-5858. DOI: 10.1099/mgen.0.000528


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