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MultiOrgan Disease and Death Associated With Streptococcus equi spp. zooepidemicus in a 2-Month-Old Foal

Artículo de investigación publicado en Journal of Equine Veterinary Science

29 de agosto de 2018

A 2-month-old Andalusian colt in central Spain presented dyspnea, diarrhea, and depression. Despite the initial treatment for presumptive pneumonia caused by Rhodococcus equi, after 1 hour, the colt showed signs of shock and died. The necropsy revealed multiple abscesses in the lung, as well as enlarged mesenteric lymph nodes, and hemorrhagic peritonitis. Samples were taken from trachea, lung parenchyma, small intestine, and colon. All samples yielded a pure culture of Streptococcus equi spp. zooepidemicus, whereas R. equi was excluded by using a specific qPCR performed on all samples. Isolates from all samples were characterized by pulse-field gel electrophoresis and the representative strain was identified by MALDI-TOF and qPCR. Its genome was sequenced, assembled, and annotated; multilocus sequence typing data assigned the strain to sequence type 70 and genes related to adhesion, bacteriocins, invasion, antimicrobial resistance, toxins, and superantigens szeN and szeP were identified in the assembled genome. The strain was susceptible to all antimicrobials tested. Our findings support the inclusion of S. zooepidemicus on an endemic farm where R. equi has been ruled out via PCR testing. S. zooepidemicus can cause multiorgan disease in foals, similar to infection in humans. The presence of superantigens in this S. zooepidemicus strain may have contributed to the fatal outcome in this clinical case




Dominguez-Gimbernat M., Florez-Cuadrado D., Steward K., Waller A., Porrero MC., Vela AI., Perez-Sancho M., de Juan L. y Cruz F..




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MultiOrgan Disease and Death Associated With Streptococcus equi spp. zooepidemicus in a 2-Month-Old Foal



Participantes:

Universidad ComplutenseServicio de Vigilancia Sanitaria Equina (SEVISEQ). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

Universidad ComplutenseDepartamento de Medicina y Cirugía Animal. Facultad de Veterinaria. Universidad Complutense (UCM).

Animal Health TrustCentre for Preventive Medicine. Animal Health Trust (AHT).

Universidad ComplutenseDepartamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).







Journal of Equine Veterinary Science
FACTOR YEAR Q
0.880 2017

NLMID: 8216840

ISSN: 0737-0806



TÍTULO: MultiOrgan Disease and Death Associated With Streptococcus equi spp. zooepidemicus in a 2-Month-Old Foal


REVISTA: J. Equine Vet. Sci.


NUMERACIÓN: 70(2018):112-116


AÑO: 2018


EDITORIAL: Wildomar, CA : William E. Jones, c1981-


AUTORES: Dominguez-Gimbernat M., Florez-Cuadrado D., Steward K., Waller A., Porrero MC., Vela AI., Perez-Sancho M., de Juan L. and Cruz F..


PARTICIPANTES VISAVET


First
Mónica Domínguez Gimbernat
6th
Ana Isabel Vela Alonso
7th
Marta Pérez Sancho
8th
Lucía de Juan Ferré
Last
Fátima Cruz López

DOI: https://doi.org/10.1016/j.jevs.2018.08.011


CITA ESTA PUBLICACIÓN:

Dominguez-Gimbernat M., Florez-Cuadrado D., Steward K., Waller A., Porrero MC., Vela AI., Perez-Sancho M., de Juan L. y Cruz F. MultiOrgan Disease and Death Associated With Streptococcus equi spp. zooepidemicus in a 2-Month-Old Foal. Journal of Equine Veterinary Science. 70(2018):112-116. 2018. (A). ISSN: 0737-0806. DOI: 10.1016/j.jevs.2018.08.011


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