Multiresistant Salmonella enterica serovar 4,[5], 12:i:- in Europe: a new pandemic strain?
Artículo de investigación publicado en Eurosurveillance
3 de junio de 2010
A marked increase in the prevalence of S. enterica serovar 4,[5],12:i:- with resistance to ampicillin, streptomycin, sulphonamides and tetracyclines (R-type ASSuT) has been noted in food-borne infections and in pigs/pig meat in several European countries in the last ten years. One hundred and sixteen strains of S. enterica serovar 4,[5],12:i:- from humans, pigs and pig meat isolated in England and Wales, France, Germany, Italy, Poland, Spain and the Netherlands were further subtyped by phage typing, pulsed-field gel electrophoresis and multilocus variable number tandem repeat analysis to investigate the genetic relationship among strains. PCR was performed to identify the fljB flagellar gene and the genes encoding resistance to ampicillin, streptomycin, sulphonamides and tetracyclines. Class 1 and 2 integrase genes were also sought. Results indicate that genetically related serovar 4,[5],12:i:- strains of definitive phage types DT193 and DT120 with ampicillin, streptomycin, sulphonamide and tetracycline resistance encoded by blaTEM, strA-strB, sul2 and tet(B) have emerged in several European countries, with pigs the likely reservoir of infection. Control measures are urgently needed to reduce spread of infection to humans via the food chain and thereby prevent the possible pandemic spread of serovar 4,[5],12:i:- of R-type ASSuT as occurred with S. Typhimurium DT104 during the 1990s
Hopkins KL., Kirchner M., Guerra B., Granier SA., Lucarelli C., Porrero MC., Jakubczak A., Threlfall EJ. y Mevius DJ.
 | Servicio de Zoonosis de Transmisión Alimentaria y Resistencia a Antimicrobianos (ZTA). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM). |
| Health Protection Agency Microbiology Services Colindale London. | |
 | Animal Health and Veterinary Laboratories Agency (AHVLA). Department for Environment, Food and Rural Affairs (Defra). |
 | Federal Institute for Risk Assessment (BfR). |
 | Agence Nationale de Sécurité Sanitaire de l´alimentation, de l´environnement et du travail (ANSES). |
 | Istituto Superiore di Sanità. |
| National Institute of Public Health – National Institute of Hygiene ((NIPH - NIH)). | |
 | Wageningen University (UR). |
 | Faculty of Veterinary Medicine. Utrecht University (UU). |
