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Multiresistant Salmonella enterica serovar 4,[5], 12:i:- in Europe: a new pandemic strain?

Artículo de investigación publicado en Eurosurveillance

3 de junio de 2010

A marked increase in the prevalence of S. enterica serovar 4,[5],12:i:- with resistance to ampicillin, streptomycin, sulphonamides and tetracyclines (R-type ASSuT) has been noted in food-borne infections and in pigs/pig meat in several European countries in the last ten years. One hundred and sixteen strains of S. enterica serovar 4,[5],12:i:- from humans, pigs and pig meat isolated in England and Wales, France, Germany, Italy, Poland, Spain and the Netherlands were further subtyped by phage typing, pulsed-field gel electrophoresis and multilocus variable number tandem repeat analysis to investigate the genetic relationship among strains. PCR was performed to identify the fljB flagellar gene and the genes encoding resistance to ampicillin, streptomycin, sulphonamides and tetracyclines. Class 1 and 2 integrase genes were also sought. Results indicate that genetically related serovar 4,[5],12:i:- strains of definitive phage types DT193 and DT120 with ampicillin, streptomycin, sulphonamide and tetracycline resistance encoded by blaTEM, strA-strB, sul2 and tet(B) have emerged in several European countries, with pigs the likely reservoir of infection. Control measures are urgently needed to reduce spread of infection to humans via the food chain and thereby prevent the possible pandemic spread of serovar 4,[5],12:i:- of R-type ASSuT as occurred with S. Typhimurium DT104 during the 1990s




Hopkins KL., Kirchner M., Guerra B., Granier SA., Lucarelli C., Porrero MC., Jakubczak A., Threlfall EJ. y Mevius DJ.




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Multiresistant Salmonella enterica serovar 4,[5], 12:i:- in Europe: a new pandemic strain?

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Multiresistant Salmonella enterica serovar 4,[5], 12:i:- in Europe: a new pandemic strain?


Participantes:

Universidad ComplutenseServicio de Zoonosis de Transmisión Alimentaria y Resistencia a Antimicrobianos (ZTA). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

Health Protection Agency Microbiology Services Colindale London.

Department for Environment, Food and Rural AffairsAnimal Health and Veterinary Laboratories Agency (AHVLA). Department for Environment, Food and Rural Affairs (Defra).

Federal Institute for Risk AssessmentFederal Institute for Risk Assessment (BfR).

Agence Nationale de Sécurité Sanitaire de l´alimentation, de l´environnement et du travailAgence Nationale de Sécurité Sanitaire de l´alimentation, de l´environnement et du travail (ANSES).

Istituto Superiore di SanitàIstituto Superiore di Sanità.

National Institute of Public Health – National Institute of Hygiene ((NIPH - NIH)).

Wageningen UniversityWageningen University (UR).

Utrecht UniversityFaculty of Veterinary Medicine. Utrecht University (UU).







Eurosurveillance
FACTOR YEAR Q
6.153 2011

NLMID: 100887452

PMID: 20546690

ISSN: 1560-7917



TÍTULO: Multiresistant Salmonella enterica serovar 4,[5], 12:i:- in Europe: a new pandemic strain?


REVISTA: Eurosurveillance


NUMERACIÓN: 15(22):19580


AÑO: 2010


EDITORIAL: European Centre for Disease Prevention and Control (ECDC)


AUTORES: Hopkins KL., Kirchner M., Guerra B., Granier SA., Lucarelli C., Porrero MC., Jakubczak A., Threlfall EJ. and Mevius DJ.


DOI: https://doi.org/10.2807/ese.15.22.19580-en


CITA ESTA PUBLICACIÓN:

Hopkins KL., Kirchner M., Guerra B., Granier SA., Lucarelli C., Porrero MC., Jakubczak A., Threlfall EJ. y Mevius DJ. Multiresistant Salmonella enterica serovar 4,[5], 12:i:- in Europe: a new pandemic strain?. Eurosurveillance. 15(22):19580. 2010. (A). ISSN: 1560-7917. DOI: 10.2807/ese.15.22.19580-en


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