Noticias de mayo de 2025
8 de mayo de 2025
Vía publiDB
Mobile integrons encode phage defense systems
Artículo de investigación publicado en Science
Integrons are bacterial genetic elements that capture, stockpile, and modulate the expression of genes encoded in integron cassettes. Mobile integrons (MIs) are borne on plasmids, acting as a vehicle for hundreds of antimicrobial resistance genes among key pathogens. These elements also carry gene cassettes of unknown function (gcus) whose role and adaptive value remain unexplored. In this work, we show that gcus encode phage resistance systems, many of which are newly discovered. Bacteriophage resistance integron cassettes (BRiCs) can be combined and mixed with resistance cassettes to produce…
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1 de mayo de 2025
Vía publiDB
Evaluation of techniques for post-mortem diagnosis of Mycobacterium tuberculosis complex infection in goats
Artículo de investigación publicado en Veterinary Microbiology
Goats are highly susceptible to Mycobacterium tuberculosis complex (MTBC) infection and can play an important role in the epidemiology of animal tuberculosis (TB) in certain epidemiological scenarios. Historically, culture has been considered the only gold standard technique for post-mortem confirmation of MTBC infection. However, it is constrained by its low sensitivity, the slow growth of MTBC, and stringent biosecurity requirements. Thus, alternative post-mortem techniques are essential for effective TB control and eradication. This study aimed to compare the use of different diagnosis tech…
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1 de mayo de 2025
Vía publiDB
Reproductive loss attributed to Lactococcus petauri infection in a black-and-white ruffed lemur
Artículo de investigación publicado en Journal of Veterinary Diagnostic Investigation
Lactococci have been associated with fetal and neonatal infections in humans and cattle. Here we describe a case of reproductive loss attributed to Lactococcus petauri in a lemur. A full-term black-and-white ruffed lemur (Varecia variegata) was found dead in the indoor area of a zoologic exhibit. Classification as a late-term abortion or stillbirth was unclear as the precise gestational time was unknown. A medical checkup of the dam revealed fever and neutrophilic leukocytosis; recovery followed treatment with enrofloxacin. The main histologic findings were placental edema and hemorrhage, hepa…
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1 de mayo de 2025
Vía publiDB
imdiTBap. Improving the diagnosis of tuberculosis in domestic ruminants through the use of new antigens and test platforms
Publicado un nuevo artículo de divulgación en German Multidisciplinary Publishing Center
The impact of zoonotic tuberculosis (TB) has been known for a long time and has
resulted in the implementation of milk pasteurization as the main preventive
measure. Livestock TB control programs were originally designed to reduce the risk
posed by zoonotic transmission to humans. Diagnosis of TB in livestock is based
primarily on cell-mediated immunity (CMI) diagnostic tests (intradermal test/IT and
interferon-gamma release assay/IGRA) using PPDs (purified protein derivatives from
Mycobacterium bovis and M. avium) that are sub-optimal in terms of sensitivity (Se)
and specificity (Sp)(1…
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