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Population genomics and antimicrobial resistance dynamics of Escherichia coli in wastewater and river environments

Investigación publicada en Communications Biology

12 de abril de 2021

Aquatic environments are key niches for the emergence, evolution and dissemination of antimicrobial resistance. However, the population diversity and the genetic elements that drive the dynamics of resistant bacteria in different aquatic environments are still largely unknown. The aim of this study was to understand the population genomics and evolutionary events of Escherichia coli resistant to clinically important antibiotics including aminoglycosides, in anthropogenic and natural water ecosystems. Here we show that less different E. coli sequence types (STs) are identified in wastewater than in rivers, albeit more resistant to antibiotics, and with significantly more plasmids/cell (6.36 vs 3.72). However, the genomic diversity within E. coli STs in both aquatic environments is similar. Wastewater environments favor the selection of conserved chromosomal structures associated with diverse flexible plasmids, unraveling promiscuous interplasmidic resistance genes flux. On the contrary, the key driver for river E. coli adaptation is a mutable chromosome along with few plasmid types shared between diverse STs harboring a limited resistance gene content




Delgado-Blas JF., Ovejero CM., David S., Montero N., Calero-Caceres W., Garcillan-Barcia MP., de la Cruz F., Muniesa M., Aanensen DM. y Gonzalez-Zorn B..




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Population genomics and antimicrobial resistance dynamics of Escherichia coli in wastewater and river environments

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Population genomics and antimicrobial resistance dynamics of Escherichia coli in wastewater and river environments


Participantes:

Universidad ComplutenseServicio de Zoonosis de Transmisión Alimentaria y Resistencia a Antimicrobianos (ZTA). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

Universidad ComplutenseDepartamento de Producción Animal. Facultad de Veterinaria. Universidad Complutense (UCM).

Wellcome Trust Sanger InstituteCentre for Genomic Pathogen Surveillance. Wellcome Trust Sanger Institute.

Universitat de BarcelonaFacultad de Biología. Universitat de Barcelona (UB).

Universidad de CantabriaUniversidad de Cantabria (UC).

Consejo Superior de Investigaciones CientíficasInstituto de Biomedicina o Biotecnología de Cantabria (IBBTEC). Consejo Superior de Investigaciones Científicas (CSIC).

Technical University of AmbatoFaculty of Food Science. Engineering and Biotechnology. Technical University of Ambato (UTA).







Communications Biology
FACTOR YEAR Q
4.165 2019

PMID: 33846529

ISSN: 2399-3642



TÍTULO: Population genomics and antimicrobial resistance dynamics of Escherichia coli in wastewater and river environments


REVISTA: Commun. Biol


NUMERACIÓN: 4(1):457


AÑO: 2021


EDITORIAL: NATURE PUBLISHING GROUP


AUTORES: Delgado-Blas JF., Ovejero CM., David S., Montero N., Calero-Caceres W., Garcillan-Barcia MP., de la Cruz F., Muniesa M., Aanensen DM. and Gonzalez-Zorn B..


PARTICIPANTES VISAVET


First
José Francisco Delgado Blas
Last
Bruno González Zorn

DOI: https://doi.org/10.1038/s42003-021-01949-x


CITA ESTA PUBLICACIÓN:

Delgado-Blas JF., Ovejero CM., David S., Montero N., Calero-Caceres W., Garcillan-Barcia MP., de la Cruz F., Muniesa M., Aanensen DM. y Gonzalez-Zorn B. Population genomics and antimicrobial resistance dynamics of Escherichia coli in wastewater and river environments. Communications Biology. 4(1):457. 2021. (A). ISSN: 2399-3642. DOI: 10.1038/s42003-021-01949-x


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