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Salmonella enterica Serovar Typhimurium Exploits Inflammation to Modify Swine Intestinal Microbiota

Frontiers in cellular and infection microbiology publica este artículo de investigación

22 de enero de 2016

Salmonella enterica serovar Typhimurium is an important zoonotic gastrointestinal pathogen responsible for foodborne disease worldwide. It is a successful enteric pathogen because it has developed virulence strategies allowing it to survive in a highly inflamed intestinal environment exploiting inflammation to overcome colonization resistance provided by intestinal microbiota. In this study, we used piglets featuring an intact microbiota, which naturally develop gastroenteritis, as model for salmonellosis. We compared the effects on the intestinal microbiota induced by a wild type and an attenuated S. Typhimurium in order to evaluate whether the modifications are correlated with the virulence of the strain. This study showed that Salmonella alters microbiota in a virulence-dependent manner. We found that the wild type S. Typhimurium induced inflammation and a reduction of specific protecting microbiota species (SCFA-producing bacteria) normally involved in providing a barrier against pathogens. Both these effects could contribute to impair colonization resistance, increasing the host susceptibility to wild type S. Typhimurium colonization. In contrast, the attenuated S. Typhimurium, which is characterized by a reduced ability to colonize the intestine, and by a very mild inflammatory response, was unable to successfully sustain competition with the microbiota




Drumo R., Pesciarioli M., Ruggeri J., Tarantino M., Chirullo B., Pistoia C., Petrucci P., Martinelli N., Moscati L., Manuali E., Pavone S., Picciolini M., Ammendola S., Gabai G., Battistoni A., Pezzotti G., Alborali GL., Napolioni V., Pasquali P. y Magistrali CF.




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Salmonella enterica Serovar Typhimurium Exploits Inflammation to Modify Swine Intestinal Microbiota

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Salmonella enterica Serovar Typhimurium Exploits Inflammation to Modify Swine Intestinal Microbiota



Participantes:

Istituto Superiore di SanitÓDepartment of Veterinary Public Health and Food Safety. Istituto Superiore di SanitÓ.

Department of Comparative Biomedicine and Food Science (BCA). UniversitÓ degli Studi di Padova (UNIPD).

Universidad ComplutenseServicio de Zoonosis de Transmisiˇn Alimentaria y Resistencia a Antimicrobianos (ZTA). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

Department of Veterinary Diagnostic. Istituto Zooprofilattico Sperimentale della Lombardia e dell Emilia Romagna (IZSLER).

Department of Research. Istituto Zooprofilattico Sperimentale della Lombardia e dell Emilia Romagna (IZSLER).

Department of Experimental Medicine. UniversitÓ degli Studi di Perugia.

Department of Biology. UniversitÓ degli Studi di Roma Tor Vergata.







FACTOR YEAR Q
4.300 2016

NLMID: 101585359

PMID: 26835435

ISSN: 2235-2988



TÍTULO: Salmonella enterica Serovar Typhimurium Exploits Inflammation to Modify Swine Intestinal Microbiota


REVISTA: Front Cell Infect Microbiol


NUMERACIÓN: 5:106


AÑO: 2016


EDITORIAL: Lausanne Frontiers Media SA


AUTORES: Drumo R., Pesciarioli M., Ruggeri J., Tarantino M., Chirullo B., Pistoia C., Petrucci P., Martinelli N., Moscati L., Manuali E., Pavone S., Picciolini M., Ammendola S., Gabai G., Battistoni A., Pezzotti G., Alborali GL., Napolioni V., Pasquali P. and Magistrali CF.


DOI: https://doi.org/10.3389/fcimb.2015.00106


CITA ESTA PUBLICACIÓN:

Drumo R., Pesciarioli M., Ruggeri J., Tarantino M., Chirullo B., Pistoia C., Petrucci P., Martinelli N., Moscati L., Manuali E., Pavone S., Picciolini M., Ammendola S., Gabai G., Battistoni A., Pezzotti G., Alborali GL., Napolioni V., Pasquali P. y Magistrali CF. Salmonella enterica Serovar Typhimurium Exploits Inflammation to Modify Swine Intestinal Microbiota. Frontiers in cellular and infection microbiology. 5:106. 2016. (A). ISSN: 2235-2988. DOI: 10.3389/fcimb.2015.00106


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