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The SOS Response Controls Integron Recombination

Investigación publicada en Science

22 de mayo de 2009

Integrons are found in the genome of hundreds of environmental bacteria but are mainly known for their role in the capture and spread of antibiotic resistance determinants among Gram-negative pathogens. We report a direct link between this system and the ubiquitous SOS response. We found that LexA controlled expression of most integron integrases and consequently regulated cassette recombination. This regulatory coupling enhanced the potential for cassette swapping and capture in cells under stress, while minimizing cassette rearrangements or loss in constant environments. This finding exposes integrons as integrated adaptive systems and has implications for antibiotic treatment policies




Guerin E., Cambray G., Sanchez-Alberola N., Campoy S., Erill I., Da Re S., Gonzalez-Zorn B., Barbe J., Ploy MC. y Mazel D.




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The SOS Response Controls Integron Recombination

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The SOS Response Controls Integron Recombination


Participantes:

Universidad ComplutenseServicio de Zoonosis de Transmisión Alimentaria y Resistencia a Antimicrobianos (ZTA). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

Universidad ComplutenseDepartamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).

Faculté de Médecine. Université de Limoges (UL).

Institut PasteurBacterial Genome Plasticity (BGP). Department of Genomes and Genetics. Institut Pasteur.

Universitat Autònoma de BarcelonaDepartament de Genètica i de Microbiologia. Universitat Autònoma de Barcelona (UAB).

Consejo Superior de Investigaciones CientíficasInstituto de Microelectrónica de Barcelona (IMB). Centro Nacional de Microelectrónica (CNM). Consejo Superior de Investigaciones Científicas (CSIC).







Science
FACTOR YEAR Q
29.747 2009

NLMID: 404511

PMID: 19460999

ISSN: 0036-8075



TÍTULO: The SOS Response Controls Integron Recombination


REVISTA: Science


NUMERACIÓN: 324(5930):1034


AÑO: 2009


EDITORIAL: American Association for the Advancement of Science


AUTORES: Guerin E., Cambray G., Sanchez-Alberola N., Campoy S., Erill I., Da Re S., Gonzalez-Zorn B., Barbe J., Ploy MC. and Mazel D.


PARTICIPANTES VISAVET


Bruno González Zorn

DOI: https://doi.org/10.1126/science.1172914


CITA ESTA PUBLICACIÓN:

Guerin E., Cambray G., Sanchez-Alberola N., Campoy S., Erill I., Da Re S., Gonzalez-Zorn B., Barbe J., Ploy MC. y Mazel D. The SOS Response Controls Integron Recombination. Science. 324(5930):1034. 2009. (A). ISSN: 0036-8075. DOI: 10.1126/science.1172914


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