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A subunit vaccine candidate based on the Spike protein of SARS-CoV-2 prevents infectious virus shedding in cats

Investigation published in Research in Veterinary Science

May 31st, 2022

Of the numerous animal species affected by the SARS-CoV-2 virus, cats are one of the most susceptible, and cat-to-cat transmission has been described. Although cat-to-human infection has not, as yet, been demonstrated, preventive measures should be taken in order to avoid both viral infection in cats and transmission among them. In this respect, the application of an effective vaccine to at-risk populations would be a useful tool for controlling the disease in this species. Here, we test a new vaccine prototype based on the Spike protein of the virus in order to prevent infection and infectious virus shedding in cats. The vaccine employed in experimentation, and which is easily produced, triggered a strong neutralizing antibody response in vaccinated animals. In contrast to that which occurred with control animals, no infectious virus was detected in the oropharyngeal or rectal swabs of vaccinated cats submitted to a SARS-CoV-2 challenge. These results are of great interest as regards future considerations related to implementing vaccination programs in pets. The value of cats as vaccination trial models is also described herein




Barroso-Arevalo S., Sánchez-Morales L., Dominguez M., Garcia-Seco T., Risalde MA., Garcia-Bocanegra I., Dominguez L. and Sanchez-Vizcaino JM..




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A subunit vaccine candidate based on the Spike protein of SARS-CoV-2 prevents infectious virus shedding in cats

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A subunit vaccine candidate based on the Spike protein of SARS-CoV-2 prevents infectious virus shedding in cats



Participants:

Universidad ComplutenseServicio de Inmunología Viral y Medicina Preventiva (SUAT). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

Universidad ComplutenseDepartamento de Producción Animal. Facultad de Veterinaria. Universidad Complutense (UCM).

Instituto de Salud Carlos IIIServicio de Inmunología. Centro Nacional de Microbiología (CNM). Instituto de Salud Carlos III (ISCIII).

Universidad de CórdobaDepartamento de Anatomía y Anatomía Patológica Comparadas. Departamento de Sanidad Animal. Facultad de Veterinaria. Universidad de Córdoba (UCO).

Universidad de CórdobaInstituto Maimonides de Investigación Biomédica de Córdoba (IMIBIC). Universidad de Córdoba (UCO).

Universidad de CórdobaHospital Universitario Reina Sofía de Córdoba. Universidad de Córdoba (UCO).







Research in Veterinary Science
FACTOR YEAR Q
2.554 2021

NLMID: 401300

PMID: 35667227

ISSN: 0034-5288



TITLE: A subunit vaccine candidate based on the Spike protein of SARS-CoV-2 prevents infectious virus shedding in cats


JOURNAL: Res. Vet. Sci.


NUMERACIÓN: 1-36


AÑO: 2022


PUBLISHER: Elsevier


AUTHORS: Barroso-Arevalo S., Sánchez-Morales L., Dominguez M., Garcia-Seco T., Risalde MA., Garcia-Bocanegra I., Dominguez L. and Sanchez-Vizcaino JM..


VISAVET PARTICIPANTS


First
Sandra Barroso Arévalo
2nd
Lidia Sánchez Morales
4th
Teresa García-Seco Romero
7th
Lucas Domínguez Rodríguez
Last
José Manuel Sánchez-Vizcaíno Rodríguez

DOI: https://doi.org/10.1016/j.rvsc.2022.05.003


CITE THIS PUBLICATION:

Barroso-Arevalo S., Sánchez-Morales L., Dominguez M., Garcia-Seco T., Risalde MA., Garcia-Bocanegra I., Dominguez L. and Sanchez-Vizcaino JM. A subunit vaccine candidate based on the Spike protein of SARS-CoV-2 prevents infectious virus shedding in cats. Research in Veterinary Science. 1-36. 2022. (A). ISSN: 0034-5288. DOI: 10.1016/j.rvsc.2022.05.003


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