Conference in EOHA 2026 Annual Scientific Meeting. International One Health Congress

May 18^th, 2026

Sánchez-Morales L., Garcia-Seco T., Vuscan P., Dominguez L., Netea M. and Perez-Sancho M.

Trained immunity refers to the long-term functional reprogramming of innate immune cells, leading to enhanced responses upon secondary stimulation. DpB is a BCG porcine-derived immunomodulator that has shown protective and immunomodulatory effects in animal models of SARS-CoV-2, Streptococcus suis and Salmonella spp. However, its capacity to induce trained immunity in human innate immune cells has not been investigated yet. Given the growing interest in trained immunity-based strategies, evaluating the effects of dpB in human monocytes may support the development of innovative complementary prophylactic tools within One Health

	Servicio de Identificación y Caracterización Microbiana (ICM). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).
	Departamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).
	Radboud University Nijmegen Medical Cente (UMCN).
	University of Bonn Medical Centre.