Improving the diagnosis of tuberculosis in domestic ruminants through the use of new antigens and test platforms. The imdiTBap project
EAVLD Newsletter publish this article
June 1st, 2025
Velasco-Reinaldos C., Ortega J., Roy A., Moreno I., Dominguez M., Jones G., Gormley E., McGill K., Boniotti MB., Bakker D., Or E., Mazzone P., Martucciello A . and Bezos J..
The impact of zoonotic tuberculosis (TB) has been known for a long time, leading to the implementation of milk pasteurization as a key preventive measure. Livestock TB control programs were originally designed to reduce the risk posed by zoonotic transmission to humans. Diagnosis of TB in livestock is based primarily on cell-mediated immunity (CMI) diagnostic tests (intradermal test/IT and interferon-gamma release assay/IGRA) using PPDs (purified protein derivatives from Mycobacterium bovis and M. avium) that are sub-optimal in terms of sensitivity (Se) and specificity (Sp). Therefore, there is a need to continue working on the development and improvement of diagnostic techniques based on CMI and humoral response
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