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Molecular and epidemiological population-based integrative analysis of human and animal Mycobacterium bovis infections in a low-prevalence setting

Veterinary Microbiology publish this investigation article

November 15th, 2016

Human Mycobacterium bovis infections are considered to be due to reactivations, when involve elderly people, or to recent transmissions, when exposure is occupational. We determined the cause of M. bovis infections by genotyping M. bovis isolates in a population-based study integrating human and animal databases. Among the 1,586 tuberculosis (TB) cases in Asturias, Northern Spain (1,080,000 inhabitants), 1567 corresponded to M. tuberculosis and 19 to M. bovis. The number of human isolates sharing genotype with cattle isolates was higher than expected (47%) for a setting with low prevalence of bovine TB and efficient control programs in cattle. The risk of exposure to infected animals was probable/possible in most of these matched cases (77.7%). Recent transmission was the likely explanation of most M. bovis infections in elderly people. A potential human-to-human transmission was found. Our study illustrates a model of collaboration between human and animal health professionals to provide a precise snapshot of the transmission of M. bovis in the human-animal interface




Palacios JJ., Navarro Y., Romero B., Penedo A., Menendez-Gonzalez A., Perez Hernandez MD., Fernandez-Verdugo A., Copano F., Torreblanca A., Bouza E., Dominguez L., de Juan L. and Garcia de Viedma D.




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Molecular and epidemiological population-based integrative analysis of human and animal Mycobacterium bovis infections in a low-prevalence setting

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Molecular and epidemiological population-based integrative analysis of human and animal Mycobacterium bovis infections in a low-prevalence setting



Participants:

Gobierno del Principado de AsturiasUnidad de Referencia Regional de Micobacterias. Hospital Universitario Central de Asturias. Servicio de Salud del Principado de Asturias (SESPA). Gobierno del Principado de Asturias.

Comunidad de MadridServicio de Microbiología y Enfermedades Infecciosas. Hospital General Universitario Gregorio Marañón. Salud Madrid. Comunidad de Madrid.

Comunidad de MadridInstituto de Investigación Sanitaria Gregorio Marañón (IISGM). Hospital General Universitario Gregorio Marañón. Salud Madrid. Comunidad de Madrid.

Instituto de Salud Carlos IIICentro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES). Instituto de Salud Carlos III (ISCIII).

CEI Campus MoncloaCEI Campus Moncloa.

Universidad ComplutenseServicio de Micobacterias (MYC). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

Gobierno del Principado de AsturiasServicio de Vigilancia y Alertas Epidemiológicas. Dirección General de Salud Pública. Consejería de Sanidad. Gobierno del Principado de Asturias.

Gobierno del Principado de AsturiasLaboratorio de Sanidad Animal. Gobierno del Principado de Asturias.

Gobierno del Principado de AsturiasServicio de Microbiología. Hospital de Cabueñes. Servicio de Salud del Principado de Asturias (SESPA). Gobierno del Principado de Asturias.

Universidad ComplutenseDepartamento de Medicina. Facultad de Medicina. Universidad Complutense (UCM).

Universidad ComplutenseDepartamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).







Veterinary Microbiology
FACTOR YEAR Q
2.628 2016

NLMID: 7705469

PMID: 27771068

ISSN: 0378-1135



TITLE: Molecular and epidemiological population-based integrative analysis of human and animal Mycobacterium bovis infections in a low-prevalence setting


JOURNAL: Vet. Microbiol.


NUMERACIÓN: 195:30-36


AÑO: 2016


PUBLISHER: Elsevier Science Publishers


AUTHORS: Palacios JJ., Navarro Y., Romero B., Penedo A., Menendez-Gonzalez A., Perez Hernandez MD., Fernandez-Verdugo A., Copano F., Torreblanca A., Bouza E., Dominguez L., de Juan L. and Garcia de Viedma D.


VISAVET PARTICIPANTS


3rd
Beatriz Romero Martínez
11th
Lucas Domínguez Rodríguez
12th
Lucía de Juan Ferré

DOI: https://doi.org/10.1016/j.vetmic.2016.08.019


CITE THIS PUBLICATION:

Palacios JJ., Navarro Y., Romero B., Penedo A., Menendez-Gonzalez A., Perez Hernandez MD., Fernandez-Verdugo A., Copano F., Torreblanca A., Bouza E., Dominguez L., de Juan L. and Garcia de Viedma D. Molecular and epidemiological population-based integrative analysis of human and animal Mycobacterium bovis infections in a low-prevalence setting. Veterinary Microbiology. 195:30-36. 2016. (A). ISSN: 0378-1135. DOI: 10.1016/j.vetmic.2016.08.019


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