Home \ Research \ Scientific publications \


National colistin sales versus colistin resistance in Spanish pig production

Research in Veterinary Science publish this investigation article

April 1st, 2019

Colistin resistance was associated with infrequent spontaneous mutations that reduce bacterial fitness until 2015, when the plasmid-mediated colistin resistance gene mcr-1 was discovered in China (Liu et al., 2016). The mcr-1 gene was reported for the first time in Southern Europe in 2016 in nine strains of Escherichia coli and Salmonella enterica from farm animals (poultry and pigs) (Quesada et al., 2016). Currently, eight different mcr genes have been reported (mcr-1 to 8) (Garcia et al., 2018) (Yang et al., 2018) (Wang et al., 2018). Nevertheless, only mcr-1, 3, and 4 have been found in Spain (Hernandez et al., 2017) (Quesada et al., 2016) (Carattoli et al., 2017).

Food-producing animals, particularly pigs, have been shown to be potential reservoirs for the dissemination of colistin resistance (Garcia et al., 2018). Antimicrobial chemotherapy, particularly colistin, has been the treatment of first choice to control Gram-negative bacteria in pig production, habitually used as a prophylactic approach (Moreno, 2014). Paradoxically, colistin is now considered to be a last resort antibiotic in human clinical practice. In 2013, the European Medicines Agency (EMA) recommended to practice responsible use of colistin, limiting its use to the treatment of animal diseases and avoiding its use for metaphylaxis (European Medicines Agency, 2013). Similarly, in July 2016, the EMA called to minimize the use of colistin in animals in the European Union (EU), aiming for a target at country level of 5 mg/population correction unit (PCU) and a desirable level of 1 mg/PCU (European Medicines Agency, 2013). Consequently, in September 2016, the Spanish Agency of Medicines and Medical Devices (AEMPS) established a voluntary strategic plan “Programa Reduce Colistina” to reduce colistin use in pigs within the Spanish Plan against antibiotic resistance (PRAN) (Plan Nacional Resistencia Antibióticos (PRAN), 2018). A total of 70% of Spanish pig production companies joined the program, representing 80% of Spanish pig production (AEMPS, 2018). We aimed to early assess the impact of these recommendations and how the drop in antibiotic use has influenced colistin resistance levels in pigs in Spain.




Miguela-Villoldo P., Hernandez M., Moreno MA., Rodriguez-Lazaro D., Quesada A., Dominguez L. and Ugarte-Ruiz M..




See this article
National colistin sales versus colistin resistance in Spanish pig production

See it on NLM PubMed
National colistin sales versus colistin resistance in Spanish pig production


Participants:

Universidad ComplutenseServicio de Zoonosis de Transmisión Alimentaria y Resistencia a Antimicrobianos (ZTA). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

Universidad ComplutenseDepartamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).

Instituto Tecnológico Agrario de Castilla y LeónLaboratorio de Biología Molecular y Microbiología. Instituto Tecnológico Agrario de Castilla y León (ITACyL).

Universidad de ValladolidTecnología de los Alimentos. Escuela Técnica Superior de Ingenierías Agrarias. Universidad de Valladolid (UVa).

Universidad de BurgosUnidad de Microbiología. Departamento de Biotecnología y Ciencia de los Alimentos. Universidad de Burgos (UBU).

Universidad de ExtremaduraDepartamento de Bioquímica, Biología Molecular y Genética. Facultad de Veterinaria. Universidad de Extremadura (UNEX).

Universidad de ExtremaduraInstituto Universitario de Biotecnología Ganadera y Cinegética (INBIO G+C). Universidad de Extremadura (UNEX).



Related news in other media:

- ¿Cuáles están siendo los resultados del Programa Reduce Colistina en porcino? - porcino.info







Research in Veterinary Science
FACTOR YEAR Q
1.751 2018

NLMID: 401300

PMID: 30660816

ISSN: 0034-5288



TITLE: National colistin sales versus colistin resistance in Spanish pig production


JOURNAL: Res. Vet. Sci.


NUMERACIÓN: 123:141-143


AÑO: 2019


PUBLISHER: Elsevier


AUTHORS: Miguela-Villoldo P., Hernandez M., Moreno MA., Rodriguez-Lazaro D., Quesada A., Dominguez L. and Ugarte-Ruiz M..


VISAVET PARTICIPANTS


First
Pedro Miguela Villoldo
3rd
Miguel Ángel Moreno Romo
6th
Lucas Domínguez Rodríguez
Last
María Ugarte Ruiz

DOI: https://doi.org/ 10.1016/j.rvsc.2019.01.010


CITE THIS PUBLICATION:

Miguela-Villoldo P., Hernandez M., Moreno MA., Rodriguez-Lazaro D., Quesada A., Dominguez L. and Ugarte-Ruiz M. National colistin sales versus colistin resistance in Spanish pig production. Research in Veterinary Science. 123:141-143. 2019. (A). ISSN: 0034-5288. DOI: 10.1016/j.rvsc.2019.01.010


UNITS: