Veterinary Microbiology publish this investigation article

October 31^st, 1997

In an attempt to obtain a model more closely resembling natural listeriosis, we studied the course of infection in mice inoculated by the intragastric route with Listeria monocytogenes. Corticosteroid-treated, and untreated mice both developed subclinical infection without mortality, but faecal shedding and persistence of bacteria in the liver and spleen of corticosteroid-treated mice were significantly more protracted than in untreated mice. Untreated mice cleared the bacteria from their livers and spleens by day 5 postinfection (PI), whereas treated mice did not clear the organisms until 8-9 days PI. In untreated mice faecal shedding lasted 5 days PI, whereas in treated mice the organisms were recovered at significantly higher levels until day 9 PI. The only intestinal lesions observed were mild pyogranulomatous changes in the dome area of some Peyer`s patches in treated mice

Prats N., Lopez S., Domingo M., Briones V., Garcia JA., Dominguez L. and Marco A.

Prolonged persistence of Listeria monocytogenes after intragastric infection in corticosteroid-treated mice

Prolonged persistence of Listeria monocytogenes after intragastric infection in corticosteroid-treated mice

	Departamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).
	Servicio de Identificación y Caracterización Microbiana (ICM). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).
	Departamento de Patología y Producciones Animales. Facultad de Veterinaria. Universitat Autònoma de Barcelona (UAB).