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Tuberculosis vaccination sequence effect on protection in wild boar

Comparative Immunology, Microbiology and Infectious Diseases publish this investigation article

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The Eurasian wild boar (Sus scrofa) is a reservoir for tuberculosis (TB) in which vaccination is a valuable tool for control. We evaluated the protection and immune response achieved by homologous and heterologous regimes administering BCG and heat-inactivated Mycobacterium bovis (IV). Twenty-one wild boar piglets were randomly allocated in five groups: Control, homologous BCG, homologous IV, heterologous IV-BCG, heterologous BCG-IV. Significant 67% and 66% total lesion score reductions were detected in homologous IV (IVx2) and heterologous IV-BCG groups when compared with Control group (F4,16 = 6.393, p = 0.003; Bonferroni Control vs IVx2 p = 0.026, Tukey Control vs IV-BCG p = 0.021). No significant differences were found for homologous BCG (although a 48% reduction in total lesion score was recorded) and BCG-IV (3% reduction). Heterologous regimes did not improve protection over homologous regimes in the wild boar model and showed variable results from no protection to similar protection as homologous regimes. Therefore, homologous regimes remain the best option to vaccinate wild boar against TB. Moreover, vaccine sequence dramatically influenced the outcome underlining the relevance of studying the effects of prior sensitization in the outcome of vaccination




Diez-Delgado I., Sevilla IA., Garrido JM., Romero B., Geijo MV., Dominguez L., Juste RA., Aranaz A., de la Fuente J. and Gortazar C.




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Tuberculosis vaccination sequence effect on protection in wild boar



Participants:

Universidad ComplutenseDepartamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).

Gobierno de Castilla-La ManchaSanidad y Biotecnología (SaBio). Instituto de Investigación en Recursos Cinegéticos (IREC). Consejo Superior de Investigaciones Científicas (CSIC). Universidad de Castilla La Mancha (UCLM). Gobierno de Castilla-La Mancha (JCCM).

Gobierno VascoNeiker-Tecnalia, Instituto Vasco de Investigación y Desarrollo Agrario. Gobierno Vasco.

Universidad ComplutenseServicio de Micobacterias (MYC). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

Oklahoma State UniversityDepartament of Veterinary Pathobiology. Center for Veterinary Health Sciences (CVHS). Oklahoma State University (OSU).

Gobierno del Principado de AsturiasServicio Regional de Investigación y Desarrollo Agroalimentario (SERIDA). Gobierno del Principado de Asturias.







Comparative Immunology, Microbiology and Infectious Diseases
FACTOR YEAR Q
1.871 2018

NLMID: 7808924

ISSN: 0147-9571



TITLE: Tuberculosis vaccination sequence effect on protection in wild boar


JOURNAL: Comp. Immunol. Microbiol. Infect. Dis.


PUBLISHER: Elsevier Science


AUTHORS: Diez-Delgado I., Sevilla IA., Garrido JM., Romero B., Geijo MV., Dominguez L., Juste RA., Aranaz A., de la Fuente J. and Gortazar C.


VISAVET PARTICIPANTS


4th
Beatriz Romero Martínez
6th
Lucas Domínguez Rodríguez

DOI: https://doi.org/ 10.1016/j.cimid.2019.101329


CITE THIS PUBLICATION:

Diez-Delgado I., Sevilla IA., Garrido JM., Romero B., Geijo MV., Dominguez L., Juste RA., Aranaz A., de la Fuente J. and Gortazar C. Tuberculosis vaccination sequence effect on protection in wild boar. Comparative Immunology, Microbiology and Infectious Diseases. In Press. (A). ISSN: 0147-9571. DOI: 10.1016/j.cimid.2019.101329


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