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Vaccination as a control strategy against Salmonella infection in pigs: A systematic review and meta-analysis of the literature

Research in Veterinary Science publish this investigation article

October 1st, 2017

Consumption or handling of improperly processed or cooked pork is considered one of the top sources for foodborne salmonellosis, a common cause of intestinal disease worldwide. Asymptomatic carrier pigs may contaminate pork at slaughtering; therefore, pre-harvest reduction of Salmonella load can contribute to reduce public health risk. Multiple studies have evaluated the impact of vaccination on controlling Salmonella in swine farms, but results are highly variable due to the heterogeneity in vaccines and vaccination protocols. Here, we report the results of an inclusive systematic review and a meta-analysis of the peer-reviewed scientific literature to provide updated knowledge on the potential effectiveness of Salmonella vaccination. A total of 126 articles describing the use of Salmonella vaccines in swine were identified, of which 44 fulfilled the inclusion criteria. Most of the studies (36/44) used live vaccines, and S. Typhimurium and S. Choleraesuis were the predominant serotypes evaluated. Vaccine efficacy was most often measured through bacteriological isolation, and pooled estimates of vaccine efficacy were obtained as the difference in the percentage of positive animals when available. Attenuated and inactivated vaccines had similar efficacy [Risk Difference = − 26.8% (− 33.8, − 19.71) and − 29.5% (− 44.4, − 14.5), respectively]. No serotype effect was observed on the efficacy recorded for attenuated vaccines; however, a higher efficacy of inactivated vaccines against S. Choleraesuis was observed, though in a reduced sample.
Results from the meta-analysis here demonstrate the impact that vaccination may have on the control of Salmonella in swine farms and could help in the design of programs to minimize the risk of transmission of certain serotypes through the food chain




de la Cruz ML., Conrado I., Nault A., Perez A., Dominguez L. and Alvarez J..




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Vaccination as a control strategy against Salmonella infection in pigs: A systematic review and meta-analysis of the literature

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Vaccination as a control strategy against Salmonella infection in pigs: A systematic review and meta-analysis of the literature

Participants:

University of MinnesotaDepartment of Veterinary Population Medicine. College of Veterinary Medicine. University of Minnesota (UMM).

University of MinnesotaVeterinary Medical Library. University of Minnesota (UMM).

Universidad ComplutenseServicio de Zoonosis Emergentes, de Baja Prevalencia y Agresivos Biológicos (NED). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).



Related news in other media:

- Beneficial but variable effect of vaccination to control Salmonella in pigs - umnswinenews.com







Research in Veterinary Science
FACTOR YEAR Q
1.616 2017

NLMID: 401300

PMID: 28340428

ISSN: 0034-5288



TITLE: Vaccination as a control strategy against Salmonella infection in pigs: A systematic review and meta-analysis of the literature


JOURNAL: Res. Vet. Sci.


NUMERACIÓN: 114:86-94


AÑO: 2017


PUBLISHER: Elsevier


AUTHORS: de la Cruz ML., Conrado I., Nault A., Perez A., Dominguez L. and Alvarez J..


VISAVET PARTICIPANTS


5th
Lucas Domínguez Rodríguez
Last
Julio Álvarez Sánchez

DOI: https://doi.org/ 10.1016/j.rvsc.2017.03.005


CITE THIS PUBLICATION:

de la Cruz ML., Conrado I., Nault A., Perez A., Dominguez L. and Alvarez J. Vaccination as a control strategy against Salmonella infection in pigs: A systematic review and meta-analysis of the literature. Research in Veterinary Science. 114:86-94. 2017. (A). ISSN: 0034-5288. DOI: 10.1016/j.rvsc.2017.03.005


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