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Adenovirus-vectored African Swine Fever Virus Antigens Cocktail Is Not Protective against Virulent Arm07 Isolate in Eurasian Wild Boar

Investigación publicada en Pathogens

28 de febrero de 2020

African swine fever (ASF) is a viral disease of domestic and wild suids for which there is currently no vaccine or treatment available. The recent spread of ASF virus (ASFV) through Europe and Asia is causing enormous economic and animal losses. Unfortunately, the measures taken so far are insufficient and an effective vaccine against ASFV needs to be urgently developed. We hypothesized that immunization with a cocktail of thirty-five rationally selected antigens would improve the protective efficacy of subunit vaccine prototypes given that the combination of fewer immunogenic antigens (between 2 and 22) has failed to elicit protective efficacy. To this end,
immunogenicity and efficacy of thirty-five adenovirus-vectored ASFV antigens were evaluated in wild boar. The treated animals were divided into different groups to test the use of BioMize adjuvant and different inoculation strategies. Forty-eight days after priming, the nine treated and two control wild boar were challenged with the virulent ASFV Arm07 isolate. All animals showed clinical signs and pathological findings consistent with ASF. This lack of protection is in line with other studies with subunit vaccine prototypes, demonstrating that there is still much room for improvement to obtain an effective subunit ASFV vaccine




Cadenas-Fernández E., Sanchez-Vizcaino JM., Kosowska A., Rivera B., Mayoral-Alegre F., Rodriguez-Bertos A., Yao J., Bray J., Lokhandwala S., Mwangi W. y Barasona JA..




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Adenovirus-vectored African Swine Fever Virus Antigens Cocktail Is Not Protective against Virulent Arm07 Isolate in Eurasian Wild Boar

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Adenovirus-vectored African Swine Fever Virus Antigens Cocktail Is Not Protective against Virulent Arm07 Isolate in Eurasian Wild Boar


Participantes:

Universidad ComplutenseServicio de Inmunología Viral y Medicina Preventiva (SUAT). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

Universidad ComplutenseDepartamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).

Universidad ComplutenseDepartamento de Medicina y Cirugía Animal. Facultad de Veterinaria. Universidad Complutense (UCM).

Kansas State UniversityDepartment of Diagnostic Medicine/Pathobiology. College of Veterinary Medicine. Kansas State University (KSU).

Texas A&M UniversityDepartment of Veterinary Pathobiology. College of Veterinary Medicine and Biomedical Sciences. Texas A&M University.







Pathogens
FACTOR YEAR Q
3.405 2018

NLMID: 101596317

PMID: 32121082

ISSN: 2076-0817



TÍTULO: Adenovirus-vectored African Swine Fever Virus Antigens Cocktail Is Not Protective against Virulent Arm07 Isolate in Eurasian Wild Boar


REVISTA: Pathogens


NUMERACIÓN: 9(171):1-14


AÑO: 2020


EDITORIAL: MDPI


AUTORES: Cadenas-Fernández E., Sanchez-Vizcaino JM., Kosowska A., Rivera B., Mayoral-Alegre F., Rodriguez-Bertos A., Yao J., Bray J., Lokhandwala S., Mwangi W. and Barasona JA..


PARTICIPANTES VISAVET


First
Estefanía Cadenas Fernández
2nd
José Manuel Sánchez-Vizcaíno Rodríguez
3rd
Aleksandra Kosowska
4th
Belén Rivera Arroyo
5th
Francisco José Mayoral Alegre
6th
Antonio Manuel Rodríguez Bertos
Last
José Ángel Barasona García-Arévalo

DOI: https://doi.org/10.3390/pathogens9030171


CITA ESTA PUBLICACIÓN:

Cadenas-Fernández E., Sanchez-Vizcaino JM., Kosowska A., Rivera B., Mayoral-Alegre F., Rodriguez-Bertos A., Yao J., Bray J., Lokhandwala S., Mwangi W. y Barasona JA. Adenovirus-vectored African Swine Fever Virus Antigens Cocktail Is Not Protective against Virulent Arm07 Isolate in Eurasian Wild Boar. Pathogens. 9(171):1-14. 2020. (A). ISSN: 2076-0817. DOI: 10.3390/pathogens9030171


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