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Association between results of diagnostic tests for bovine tuberculosis and Johne`s disease in cattle

Investigación publicada en The Veterinary Record

In Press

BACKGROUND:
Bovine tuberculosis (bTB) diagnosis is impaired by numerous factors including cross-reactivity with Mycobacterium avium subspecies paratuberculosis, which causes Johne`s disease (JD). In addition, the effect of repeated bTB-intradermal testing on the performance of JD diagnostic tests is not fully understood. This study aimed to evaluate the impact of repeated bTB-intradermal tests under field conditions in Spain on the JD serological status of cattle.

METHODS:
bTB-positive herds (n=264) from Castilla-y-Leon region were selected and matched with officially tuberculosis-free control herds. The association between JD and bTB status at the herd level was assessed using conditional logistic regression and, in herds with both JD-positive and bTB-positive animals, a Bayesian hierarchical mixed-effect model was used for individual-level analysis.

RESULTS:
A significantly higher risk of being JD positive (OR: 1.48; 95 per cent CI: 1.01 to 2.15) was found for bTB-positive herds compared with controls. Individual results indicated that cattle tested more than three times per year, within the last 90 days and more than 12 months were more likely to be JD positive. A skin test-related boost in antibody response could be the cause of an apparent increase of the sensitivity of the JD-absorbed ELISA.

CONCLUSION:
The results demonstrate the interaction between bTB repeated testing and JD individual and herd-level results and this improved knowledge will facilitate the design of more effective control programmes in herds coinfected with two of the most important endemic diseases affecting cattle in Spain




Picasso C., Grau A., Bakker D., Nacar J., Minguez O., Perez A. y Alvarez J..




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Association between results of diagnostic tests for bovine tuberculosis and Johne`s disease in cattle

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Association between results of diagnostic tests for bovine tuberculosis and Johne`s disease in cattle


Participantes:

University of MinnesotaDepartment of Veterinary Population Medicine. College of Veterinary Medicine. University of Minnesota (UMM).

Universidad de la RepúblicaFacultad de Veterinaria. Universidad de la República.

Junta de Castilla y LeónServicio de Sanidad Animal. Junta de Castilla y León.

Universidad ComplutenseCentro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

Universidad ComplutenseFacultad de Veterinaria. Universidad Complutense (UCM).







The Veterinary Record
FACTOR YEAR Q
2.101 2018

NLMID: 31164

PMID: 31554708

ISSN: 0042-4900



TÍTULO: Association between results of diagnostic tests for bovine tuberculosis and Johne`s disease in cattle


REVISTA: Vet. Rec.


EDITORIAL: British Veterinary Medicine


AUTORES: Picasso C., Grau A., Bakker D., Nacar J., Minguez O., Perez A. and Alvarez J..


PARTICIPANTES VISAVET


Julio Álvarez Sánchez

DOI: https://doi.org/10.1136/vr.105336


CITA ESTA PUBLICACIÓN:

Picasso C., Grau A., Bakker D., Nacar J., Minguez O., Perez A. y Alvarez J. Association between results of diagnostic tests for bovine tuberculosis and Johne`s disease in cattle. The Veterinary Record. In Press. (A). ISSN: 0042-4900. DOI: 10.1136/vr.105336