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Bcl-2 Immunoexpression in Feline Epitheliotropic Intestinal T-Cell Lymphomas

Investigación publicada en Veterinary sciences

31 de marzo de 2022

Abstract: Lymphoma is the most common malignant hematopoietic neoplasm in domestic felines. Twenty-two cases of feline epitheliotropic duodenal T-cell lymphoma were characterized morphologically and immunohistochemically (CD3, Pax5, Ki-67), and Bcl-2 immunoexpression was established. Most cases were in domestic shorthair cats (88.2%), with a mean age of 11.2 years. All lymphomas were CD3+, with a low-to-moderate expression of Ki-67 (< 30%). A correlation between the tumoral pattern of infiltration in the lamina propria and the intraepithelial distribution of the neoplastic lymphocytes was established (p = 0.0155). Intraepithelial nests of neoplastic lymphocytes were predominantly observed in lymphomas with a patchy distribution in the lamina propria, whereas intraepithelial plaques were seen in lymphomas with an obliteration pattern. Bcl-2 was expressed in neoplastic cells in all cases, and a higher expression was associated with increased villous stunting (p = 0.0221), and tended to be present in those cases with increased epithelial damage. The expression of Bcl-2 and the degree of epitheliotropism were correlated with neoplastic progression in epitheliotropic intestinal T-cell lymphomas; those displaying high Bcl-2 immunoexpression showed increased villous stunting and epithelial damage, suggesting that Bcl-2 is overexpressed in advanced tumor stages, and may be used as a predictor of tumoral behavior in feline epitheliotropic intestinal T-cell lymphomas. This entity showed many similarities with human MEITL, so the latter entity should be considered in further lymphoma classifications of domestic animals




Rebollada A., Porras-Gonzalez N., Calvo-Ibbitson A., Rodriguez-Franco F. y Rodriguez-Bertos A..




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Bcl-2 Immunoexpression in Feline Epitheliotropic Intestinal T-Cell Lymphomas





Participantes:

Universidad ComplutenseServicio de Patología y Veterinaria Forense (SAP). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

Universidad ComplutenseDepartamento de Medicina y Cirugía Animal. Facultad de Veterinaria. Universidad Complutense (UCM).

VetPatólogos.







Veterinary sciences
FACTOR YEAR Q
2.304 2020

NLMID: 1015254153

ISSN: 2306-7381



TÍTULO: Bcl-2 Immunoexpression in Feline Epitheliotropic Intestinal T-Cell Lymphomas


REVISTA: Vet Sci


NUMERACIÓN: 9:168


AÑO: 2022


EDITORIAL: MDPI


AUTORES: Rebollada A., Porras-Gonzalez N., Calvo-Ibbitson A., Rodriguez-Franco F. and Rodriguez-Bertos A..


PARTICIPANTES VISAVET


First
Agustín Miguel Rebollada Merino
2nd
Néstor Porras González
Last
Antonio Manuel Rodríguez Bertos

DOI: https://doi.org/10.3390/vetsci9040168


CITA ESTA PUBLICACIÓN:

Rebollada A., Porras-Gonzalez N., Calvo-Ibbitson A., Rodriguez-Franco F. y Rodriguez-Bertos A. Bcl-2 Immunoexpression in Feline Epitheliotropic Intestinal T-Cell Lymphomas. Veterinary sciences. 9:168. 2022. (A). ISSN: 2306-7381. DOI: 10.3390/vetsci9040168


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