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Canine Nervous System Lymphoma Subtypes Display Characteristic Neuroanatomical Patterns

Artículo de investigación publicado en Veterinary Pathology

1 de enero de 2017

Primary and secondary nervous system involvement occurs in 4% and 5%-12%, respectively, of all canine non-Hodgkin lymphomas. The recent new classification of canine malignant lymphomas, based on the human World Health Organization classification, has been endorsed with international acceptance. This histological and immunocytochemical classification provides a unique opportunity to study the histologic anatomic distribution patterns in the central and peripheral nervous system of these defined lymphoma subtypes. In this study, we studied a cohort of 37 dogs with lymphoma, which at necropsy had either primary (n = 1, 2.7%) or secondary (n = 36; 97.3%) neural involvement. These T- (n = 16; 43.2%) or B-cell (n = 21; 56.8%) lymphomas were further classified into 12 lymphoma subtypes, with predominant subtypes including peripheral T-cell lymphoma (PTCL) or diffuse large B-cell lymphoma (DLBCL), respectively. This systematic study identified 6 different anatomically based histologically defined patterns of lymphoma infiltration in the nervous system of dogs. Different and distinct combinations of anatomical patterns correlated with specific lymphoma subtypes. Lymphoma infiltration within the meningeal, perivascular, and periventricular compartments were characteristic of DLBCL, whereas peripheral nerve involvement was a frequent feature of PTCL. Similarly cell counts above 64 cells/μL in cerebrospinal samples correlated best with marked meningeal and periventricular lymphoma infiltration histologically. Prospective studies are needed in order to confirm the hypothesis that these combinations of histological neuroanatomic patterns reflect targeting of receptors specific for the lymphoma subtypes at these various sites




Siso S., Marco-Salazar P., Moore PF., Sturges BK., Vernau W., Wisner ER., Bollen AW., Dickinson PJ. y Higgins RJ.




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Canine Nervous System Lymphoma Subtypes Display Characteristic Neuroanatomical Patterns

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Canine Nervous System Lymphoma Subtypes Display Characteristic Neuroanatomical Patterns


Participantes:

University of California-DavisDepartment of Pathology, Microbiology and Immunology. Surgical and Radiological Sciences. School of Veterinary Medicine. University of California-Davis (UCDAVIS).

Universidad ComplutenseServicio de Patología y Veterinaria Forense (SAP). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

University of California San FranciscoNeuropathology Service. Pathology & Laboratory Medicine. University of California San Francisco (UCSF).







Veterinary Pathology
FACTOR YEAR Q
1.795 2017

NLMID: 312020

PMID: 27511313

ISSN: 0300-9858



TÍTULO: Canine Nervous System Lymphoma Subtypes Display Characteristic Neuroanatomical Patterns


REVISTA: Vet. Pathol.


NUMERACIÓN: 54(1):53-60


AÑO: 2017


EDITORIAL: American College of Veterinary Pathologists


AUTORES: Siso S., Marco-Salazar P., Moore PF., Sturges BK., Vernau W., Wisner ER., Bollen AW., Dickinson PJ. and Higgins RJ.


DOI: https://doi.org/10.1177/0300985816658101


CITA ESTA PUBLICACIÓN:

Siso S., Marco-Salazar P., Moore PF., Sturges BK., Vernau W., Wisner ER., Bollen AW., Dickinson PJ. y Higgins RJ. Canine Nervous System Lymphoma Subtypes Display Characteristic Neuroanatomical Patterns. Veterinary Pathology. 54(1):53-60. 2017. (A). ISSN: 0300-9858. DOI: 10.1177/0300985816658101


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