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Distinct African Swine Fever Virus Shedding in Wild Boar Infected with Virulent and Attenuated Isolates

Vaccines publica este artículo de investigación

16 de diciembre de 2020

Abstract: Since the reappearance of African swine fever virus (ASFV), the disease has spread in an unprecedented animal pandemic in Eurasia. ASF currently constitutes the greatest global problem for the swine industry. The wild boar (Sus scrofa) in which the pathogen has established wild self-sustaining cycles, is a key reservoir for ASFV, signifying that there is an urgent need to develop an effective vaccine against this virus. Current scientific debate addresses whether live attenuated vaccines (LAVs), which have shown promising results in cross-protection of susceptible hosts, may be feasible for vaccinations carried out owing to safety concerns. The objective of this study was, therefore, to compare the ASFV shedding in wild boar infected with virulent and attenuated (LAV) isolates. Different shedding routes (oral fluid and feces) and viremia rates were characterized in wild boar inoculated with Lv17/WB/Rie1 isolate (n = 12) when compared to those inoculated with the virulent Armenia07 isolate (n = 17). In general, fewer animals infected with the Lv17/WB/Rie1 isolate tested positive for ASFV in blood, oral fluid, and feces in comparison to animals infected with the virulent Armenia07 isolate. The shedding patterns were characterized in order to understand the transmission dynamics. This knowledge will help evaluate the shedding of new LAV candidates in wild boar populations, including the comparison with gene deletion mutant LAVs, whose current results are promising




Kosowska A., Cadenas-Fernández E., Barroso-Arevalo S., Sanchez-Vizcaino JM. y Barasona JA..




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Distinct African Swine Fever Virus Shedding in Wild Boar Infected with Virulent and Attenuated Isolates

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Distinct African Swine Fever Virus Shedding in Wild Boar Infected with Virulent and Attenuated Isolates


Participantes:

Universidad ComplutenseServicio de Inmunología Viral y Medicina Preventiva (SUAT). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

Universidad ComplutenseDepartamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).







Vaccines
FACTOR YEAR Q
4.086 2019

PMID: 33339147

ISSN: 2076-393X



TÍTULO: Distinct African Swine Fever Virus Shedding in Wild Boar Infected with Virulent and Attenuated Isolates


REVISTA: Vaccines


NUMERACIÓN: 8:767


AÑO: 2020


EDITORIAL: MDPI Basel


AUTORES: Kosowska A., Cadenas-Fernández E., Barroso-Arevalo S., Sanchez-Vizcaino JM. and Barasona JA..


PARTICIPANTES VISAVET


First
Aleksandra Kosowska
2nd
Estefanía Cadenas Fernández
3rd
Sandra Barroso Arévalo
4th
José Manuel Sánchez-Vizcaíno Rodríguez
Last
José Ángel Barasona García-Arévalo

DOI: https://doi.org/10.3390/vaccines8040767


CITA ESTA PUBLICACIÓN:

Kosowska A., Cadenas-Fernández E., Barroso-Arevalo S., Sanchez-Vizcaino JM. y Barasona JA. Distinct African Swine Fever Virus Shedding in Wild Boar Infected with Virulent and Attenuated Isolates. Vaccines. 8:767. 2020. (A). ISSN: 2076-393X. DOI: 10.3390/vaccines8040767


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