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Effects of an antioxidant diet on the oxidative stress biomakers on sheltered dogs

Ponencia en 22nd Annual Congress for ESVCP&ACCP

26 de junio de 2020

Cruz F., Cabanes D., Camino E., Perez-Sancho M., Rodriguez-Bertos A., Barcena C. y Dominguez L.

Background: Oxidative stress is a consequence of the accumulation of oxygen
reactive species, nitrogen reactive species and other free radicals. Factors
associated to oxidative stress in dogs include physical exercise, several pathologies and psychogenic stress. The latter is common in sheltered dogs; therefore a balanced antioxidant diet may be a valid approach to restoring a good cell metabolism and neutralizing an excess of free radicals.
Objective: The aim of this study was to evaluate the effect of a diet enriched with
antioxidant compounds on the oxidative stress of dogs lodged long-term in an animal shelter.
Methods: A total of 10 healthy dogs were enrolled in the study, after a routine
veterinary check, a basic haematology and biochemistry profile and negative
immunofluorescence result for canine Leishmaniasis. The dogs were distributed in
two groups [6 dogs were fed a diet enriched with antioxidants (AO) and 4 dogs were fed a similar diet without antioxidants (control)]. Both diets were fed ad libitum for 4 months. A blood sample without anticoagulant was drawn at day 0 and again after 4 months; oxidative stress biomarkers analysed included Total Antioxidant Status (TAS), Thiobarbituric Acid Reactive Substances (TBARS) and 8-hydroxy-2’- deoxyguanosine (8-OhdG). Results for each group were compared between day 0 and day 120 using a Mann-Whitney U test.
Results: Dogs in the control group showed a statistically significant difference for 8- OhdG results, which were increased at day 120 (p= 0.02) showing oxidative damage in the DNA in these dogs. Conversely, dogs fed the AO diet showed significant differences between day 0 and day 120 for TAS and TBARS; TAS increased (p=0.003), while TBARS decreased at day 120 (p= 0.02), showing a better oxidative status of these dogs after four months with the AO diet.
Conclusion: This study confirmed that feeding a diet rich in antioxidants was
benefitial to regulate the oxidative status of dogs in a shelter, which could aid to
prevent damage due to oxidative stress and therefore improve the general health
status in these dogs




Participantes:

Universidad ComplutenseCentro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

Universidad ComplutenseDepartamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).

Universidad ComplutenseDepartamento de Medicina y Cirugía Animal. Facultad de Veterinaria. Universidad Complutense (UCM).


Enlace a 22nd Annual Congress for ESVCP&ACCP





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22nd Annual Congress for ESVCP&ACCP


24-27 junio de 2020
Madrid
España

TÍTULO: Effects of an antioxidant diet on the oxidative stress biomakers on sheltered dogs


TIPO: Comunicación oral


AUTORES: Cruz F., Cabanes D., Camino E., Perez-Sancho M., Rodriguez-Bertos A., Barcena C. y Dominguez L.


PARTICIPANTES VISAVET


First
Fátima Cruz López
2nd
Dario Cabañes Rodríguez
4th
Marta Pérez Sancho
5th
Antonio Manuel Rodríguez Bertos
6th
Carmen Bárcena Asensio
Last
Lucas Domínguez Rodríguez

FECHA: 26 de junio de 2020



CITA ESTA COMUNICACIÓN:

Cruz F., Cabanes D., Camino E., Perez-Sancho M., Rodriguez-Bertos A., Barcena C. y Dominguez L. Effects of an antioxidant diet on the oxidative stress biomakers on sheltered dogs. 22nd Annual Congress for ESVCP&ACCP, American College of Clinical Pharmacy, Madrid, España, 26 de junio de 2020. (Comunicación oral)