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Epidemiological impacts of attenuated African swine fever virus circulating in wild boar populations

Research in Veterinary Science publica este artículo de investigación

1 de septiembre de 2023

African swine fever virus (ASFV) genotype II has been present in wild boar in the European Union since 2014. Control measures have reduced the incidence of the ASF, but highly virulent as well as attenuated ASFV strains continue to circulate. We present the intraherd epidemiological parameters of low and highly virulent ASFV in wild boar from experimental data, and for the first time, evaluate the impact of attenuated strain circulation through unique deterministic compartmental model simulations under various potential scenarios and hypotheses. Using an estimated PCR infectious threshold of TPCR = 36.4, we obtained several transmission parameters, like an Rx (experimental intraherd R0) value of 4.5. We also introduce two novel epidemiological parameters: infectious power and resistance power, which indicate the ability of animals to transmit the infection and the reduction in infectiousness after successive exposures to varying virulence strains, respectively. The presence of ASFV attenuated strains results in 4-17% of animals either remaining in a carrier state or becoming susceptible again when exposed to highly virulent ASFV for more than two years. The timing between exposures to viruses of different virulence also influences the percentage of animals that die or remain susceptible. The findings of this study can be utilized in epidemiological modelling and provide insight into important risk situations that should be considered for surveillance and future potential ASF vaccination strategies in wild boar




Martinez-Aviles M., Bosch J., Ivorra B., Ramos AM., Ito S., Barasona JA. y Sanchez-Vizcaino JM..




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Epidemiological impacts of attenuated African swine fever virus circulating in wild boar populations

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Epidemiological impacts of attenuated African swine fever virus circulating in wild boar populations



Participantes:

Centro de Investigación en Sanidad Animal CISA-INIA.

Consejo Superior de Investigaciones CientíficasConsejo Superior de Investigaciones Científicas (CSIC).

Universidad ComplutenseServicio de Inmunología Viral y Medicina Preventiva (SUAT). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

Universidad ComplutenseDepartamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).

Universidad ComplutenseInterdisciplinary Mathematics Institute (IMI). Facultad de Ciencias Matemáticas. Universidad Complutense (UCM).







Research in Veterinary Science
FACTOR YEAR Q
2.200 2023

NLMID: 401300

PMID: 37531717

ISSN: 0034-5288



TÍTULO: Epidemiological impacts of attenuated African swine fever virus circulating in wild boar populations


REVISTA: Res Vet Sci


NUMERACIÓN: 162:104964


AÑO: 2023


EDITORIAL: Elsevier


AUTORES: Martinez-Aviles M., Bosch J., Ivorra B., Ramos AM., Ito S., Barasona JA. and Sanchez-Vizcaino JM..


First
Marta Martínez Avilés
2nd
Jaime Bosch López
6th
José Ángel Barasona García-Arévalo
Last
José Manuel Sánchez-Vizcaíno Rodríguez

DOI: https://doi.org/10.1016/j.rvsc.2023.104964


CITA ESTA PUBLICACIÓN:

Martinez-Aviles M., Bosch J., Ivorra B., Ramos AM., Ito S., Barasona JA. y Sanchez-Vizcaino JM. Epidemiological impacts of attenuated African swine fever virus circulating in wild boar populations. Research in Veterinary Science. 162:104964. 2023. (A). ISSN: 0034-5288. DOI: 10.1016/j.rvsc.2023.104964


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