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Eurasian wild boar response to skin-testing with mycobacterial and non-mycobacterial antigens

Preventive Veterinary Medicine publica este artículo de investigación

1 de septiembre de 2010

Eurasian wild boar (Sus scrofa) are able to maintain bovine tuberculosis (bTB) in the wild and are most probably able to transmit the disease to other species, thus acting as a true wildlife reservoir. Translocation of wild boar is a common practice in European countries. Therefore, identifying effective tools for bTB diagnosis in living wild boar is crucial for the implementation of control measures. We describe for the first time the sex and origin related differences in the skin-test response to mycobacterial antigens (bPPD and aPPD) and to a non-mycobacterial antigen (PHA, a plant derived mitogen) in wild and farmed wild boar, and used a small sample of known M. bovis infected wild boar to establish whether skin-testing is an option for bTB diagnosis in living wild boar. The highest skinfold increase response was detected at the PHA injection site, evidencing that the PHA test could be useful in monitoring cell mediated immunity (CMI) in wild boar populations. A clear age-increasing trend of the PHA response indicated that age should be taken into account when measuring CMI in wild boar. Origin related differences in the response against mycobacterial antigens could reflect differential exposure to mycobacterial antigens. Skin testing in BCG immunized wild boar showed low sensitivity (43-57%), while the sensitivity was good in the culture positive controls (75-100%), depending on the reading criterion. Specificity improved when the criterion was a response to bPPD larger than 2mm and bPPD response larger than aPPD response (77%). Although a limited sample, our results indicated the potential of skin test as a bTB diagnostic tool in Eurasian wild boar. However, handling of wild boar is dangerous, specificity is low, and more effort is needed in order to define the sensitivity of this technique. Copyright © 2010 Elsevier B.V. All rights reserved




Jaroso R., Vicente J., Fernandez de Mera IG., Aranaz A. y Gortazar C.




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Eurasian wild boar response to skin-testing with mycobacterial and non-mycobacterial antigens

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Eurasian wild boar response to skin-testing with mycobacterial and non-mycobacterial antigens


Participantes:

Universidad ComplutenseServicio de Micobacterias (MYC). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

Universidad ComplutenseDepartamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).

Gobierno de Castilla-La ManchaSanidad y Biotecnología (SaBio). Instituto de Investigación en Recursos Cinegéticos (IREC). Consejo Superior de Investigaciones Científicas (CSIC). Universidad de Castilla La Mancha (UCLM). Gobierno de Castilla-La Mancha (JCCM).







Preventive Veterinary Medicine
FACTOR YEAR Q
2.121 2010

NLMID: 8217463

PMID: 20633938

ISSN: 0167-5877



TÍTULO: Eurasian wild boar response to skin-testing with mycobacterial and non-mycobacterial antigens


REVISTA: Prev. Vet. Med.


NUMERACIÓN: 96(3-4):211-217


AÑO: 2010


EDITORIAL: Elsevier Science Publishers


AUTORES: Jaroso R., Vicente J., Fernandez de Mera IG., Aranaz A. and Gortazar C.


DOI: https://doi.org/10.1016/j.prevetmed.2010.06.011


CITA ESTA PUBLICACIÓN:

Jaroso R., Vicente J., Fernandez de Mera IG., Aranaz A. y Gortazar C. Eurasian wild boar response to skin-testing with mycobacterial and non-mycobacterial antigens. Preventive Veterinary Medicine. 96(3-4):211-217. 2010. (A). ISSN: 0167-5877. DOI: 10.1016/j.prevetmed.2010.06.011


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