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Experimental infection of European red deer (Cervus elaphus) with bluetongue virus serotypes 1 and 8

Veterinary Microbiology publica este artículo de investigación

28 de septiembre de 2010

Bluetongue (BT) is a climate change-related emerging infectious disease in Europe. Outbreaks of serotypes 1, 2, 4, 6, 8, 9, 11, and 16 are challenging Central and Western Europe since 1998. Measures to control or eradicate bluetongue virus (BTV) from Europe have been implemented, including movement restrictions and vaccination of domestic BTV-susceptible ruminants. However, these measures are difficult to apply in wild free-ranging hosts of the virus, like red deer (Cervus elaphus), which could play a role in the still unclear epidemiology of BT in Europe. We show for the first time that BTV RNA can be detected in European red deer blood for long periods, comparable to those of domestic ruminants, after experimental infection with BTV-1 and BTV-8. BTV RNA was detected in experimentally infected red deer blood up to the end of the study (98-112dpi). BTV-specific antibodies were found in serum both by enzyme-linked immunosorbent assay (ELISA) and virus neutralization (VNT) from 8 to 12dpi to the end of the study, peaking at 17-28dpi. Our results indicate that red deer can be infected with BTV and maintain BTV RNA for long periods, remaining essentially asymptomatic. Thus, unvaccinated red deer populations have the potential to be a BT reservoir in Europe, and could threaten the success of the European BTV control strategy. Therefore, wild and farmed red deer should be taken into account for BTV surveillance, and movement restrictions and vaccination schemes applied to domestic animals should be adapted to include farmed or translocated red deer




Lopez-Olvera JR., Falconi C., Fernandez-Pacheco P., Fernandez-Pinero J., Sanchez MA., Palma A., Herruzo I., Vicente J., Jimenez-Clavero MA., Arias M., Sanchez-Vizcaino JM. y Gortazar C.




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Experimental infection of European red deer (Cervus elaphus) with bluetongue virus serotypes 1 and 8

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Experimental infection of European red deer (Cervus elaphus) with bluetongue virus serotypes 1 and 8


Participantes:

Universidad ComplutenseServicio de Inmunología Viral y Medicina Preventiva (SUAT). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

Universidad ComplutenseDepartamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).

Universitat Autònoma de BarcelonaServicio de Ecopatología de Fauna Salvaje (SEFaS). Universitat Autònoma de Barcelona (UAB).

Gobierno de Castilla-La ManchaSanidad y Biotecnología (SaBio). Instituto de Investigación en Recursos Cinegéticos (IREC). Consejo Superior de Investigaciones Científicas (CSIC). Universidad de Castilla La Mancha (UCLM). Gobierno de Castilla-La Mancha (JCCM).

Centro de Investigación en Sanidad Animal (CISA). Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA). Ministerio de Ciencia e Innovación.







Veterinary Microbiology
FACTOR YEAR Q
3.256 2010

NLMID: 7705469

PMID: 20395075

ISSN: 0378-1135



TÍTULO: Experimental infection of European red deer (Cervus elaphus) with bluetongue virus serotypes 1 and 8


REVISTA: Vet. Microbiol.


NUMERACIÓN: 145(1-2):148-52


AÑO: 2010


EDITORIAL: Elsevier Science Publishers


AUTORES: Lopez-Olvera JR., Falconi C., Fernandez-Pacheco P., Fernandez-Pinero J., Sanchez MA., Palma A., Herruzo I., Vicente J., Jimenez-Clavero MA., Arias M., Sanchez-Vizcaino JM. and Gortazar C.


PARTICIPANTES VISAVET


José Manuel Sánchez-Vizcaíno Rodríguez

DOI: https://doi.org/10.1016/j.vetmic.2010.03.012


CITA ESTA PUBLICACIÓN:

Lopez-Olvera JR., Falconi C., Fernandez-Pacheco P., Fernandez-Pinero J., Sanchez MA., Palma A., Herruzo I., Vicente J., Jimenez-Clavero MA., Arias M., Sanchez-Vizcaino JM. y Gortazar C. Experimental infection of European red deer (Cervus elaphus) with bluetongue virus serotypes 1 and 8. Veterinary Microbiology. 145(1-2):148-52. 2010. (A). ISSN: 0378-1135. DOI: 10.1016/j.vetmic.2010.03.012


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