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First Oral Vaccination of Eurasian Wild Boar Against African Swine Fever Virus Genotype II

Investigación publicada en Frontiers in veterinary science

26 de abril de 2019

African swine fever (ASF), the most significant threat to the pig industry worldwide, has spread to more than 55 countries on three continents, and it affects more than 77% of the world swine population. In the European Union, wild boar (Sus scrofa) is the most severely affected host. The main reasons for the unprecedented and constant spread of ASF in Europe are the trade activities, the continuous movement of infected-wild boar populations among regions and the lack of vaccine to prevent ASF infection. In this study, we demonstrate that oral immunization of wild boar with a non-hemadsorbing, attenuated ASF virus of genotype II isolated in Latvia in 2017 (Lv17/WB/Rie1) conferred 92% protection against challenge with a virulent ASF virus isolate (Arm07). This is, to our knowledge, the first report of a promising vaccine against ASF virus in wild boar by oral administration. Further studies should assess the safety of repeated administration and overdose, characterize long-term shedding and verify the genetic stability of the vaccine virus to confirm if Lv17/WB/Rie1 could be used for free-ranging wild boar in ASF control programs




Barasona JA., Gallardo C., Cadenas-Fernández E., Jurado C., Rivera B., Rodriguez-Bertos A., Arias M. y Sanchez-Vizcaino JM..




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First Oral Vaccination of Eurasian Wild Boar Against African Swine Fever Virus Genotype II



Participantes:

Universidad ComplutenseServicio de Inmunología Viral y Medicina Preventiva (SUAT). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

Universidad ComplutenseDepartamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).

Instituto Nacional de Investigación y Tecnología Agraria y AlimentariaEuropean Union Reference Laboratory for African Swine Fever. Centro de Investigación en Sanidad Animal (CISA). Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA).

Universidad ComplutenseDepartamento de Medicina y Cirugía Animal. Facultad de Veterinaria. Universidad Complutense (UCM).



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- Avances en la vacuna española contra la Peste Porcina Africana - animalshealth.es

- Primera vacuna oral para combatir el virus de la peste porcina africana - diarioveterinario.com

- Científicos españoles desarrollan una vacuna que inmuniza al 92% contra la peste porcina africana - cazaworld.com







Frontiers in veterinary science
FACTOR YEAR Q
N/A

NLMID: 101666658

ISSN: 2297-1769



TÍTULO: First Oral Vaccination of Eurasian Wild Boar Against African Swine Fever Virus Genotype II


REVISTA: Front Vet Sci


NUMERACIÓN: 6(137):1-10


AÑO: 2019


EDITORIAL: Lausanne : Frontiers Media S.A


AUTORES: Barasona JA., Gallardo C., Cadenas-Fernández E., Jurado C., Rivera B., Rodriguez-Bertos A., Arias M. and Sanchez-Vizcaino JM..


PARTICIPANTES VISAVET


First
José Ángel Barasona García-Arévalo
3rd
Estefanía Cadenas Fernández
4th
Cristina Jurado Díaz
5th
Belén Rivera Arroyo
6th
Antonio Manuel Rodríguez Bertos
Last
José Manuel Sánchez-Vizcaíno Rodríguez

DOI: https://doi.org/10.3389/fvets.2019.00137


CITA ESTA PUBLICACIÓN:

Barasona JA., Gallardo C., Cadenas-Fernández E., Jurado C., Rivera B., Rodriguez-Bertos A., Arias M. y Sanchez-Vizcaino JM. First Oral Vaccination of Eurasian Wild Boar Against African Swine Fever Virus Genotype II. Frontiers in veterinary science. 6(137):1-10. 2019. (A). ISSN: 2297-1769. DOI: 10.3389/fvets.2019.00137


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