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Intrapancreatic accessory spleens in African swine fever infection of wild boar (Sus scrofa)

Artículo de investigación publicado en Frontiers in veterinary science

12 de diciembre de 2023

Intrapancreatic accessory spleen (IPAS) is one of the most frequent congenital splenic anomalies in humans; however, studies in veterinary medicine are scarce. This study aimed to describe the macroscopic, histopathological and immunohistochemical features of 11 suspected cases of IPAS in wild boar piglets of 3–4 months old. Seven of the 11 animals were immunised with a low virulence isolate of African swine fever virus (ASFV) and subsequently challenged with a highly virulent ASFV isolate (LVI-HVI group). The remaining four animals were exclusively infected with a highly virulent isolate of ASFV (HVI group). Grossly, lesions comprised focal or multifocal reddish areas of variable shape, located on the surface of the pancreatic tail or within the parenchyma. Histological and immunohistochemical studies (anti-CD79 and CD3) confirmed the presence of IPAS in eight of the 11 cases. IPAS shared the same histological structure and alterations as those observed in the original spleen. The immunohistochemical study against ASFV revealed the presence of VP72+ cells in both the spleen and IPAS of seven of the eight piglets. The results of this study describe for the first time the presence of IPAS in ASFV infection of wild boar (Sus scrofa) regardless the isolate and suggest that the infection may induce the development of ectopic splenic tissue due to an increased demand for phagocytic cells from the reticuloendothelial system. However, further studies are needed to understand the immunological mechanisms that trigger the formation of these accessory organs




Porras N., Chinchilla-Rodríguez B., Rodriguez-Bertos A., Barasona JA., Kosowska A., Vazquez-Fernandez E., Sanchez-Cordon PJ. y Sanchez-Vizcaino JM..




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Intrapancreatic accessory spleens in African swine fever infection of wild boar (Sus scrofa)

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Intrapancreatic accessory spleens in African swine fever infection of wild boar (Sus scrofa)



Participantes:

Universidad ComplutenseServicio de Patología y Veterinaria Forense (SAP). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

Universidad ComplutenseDepartamento de Producción Animal. Departamento de Medicina y Cirugía Animal. Departamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).

Instituto Nacional de Investigación y Tecnología Agraria y AlimentariaCentro de Investigación en Sanidad Animal (CISA). Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA).







Frontiers in veterinary science
FACTOR YEAR Q
2.600 2023

NLMID: 101666658

PMID: 38155760

ISSN: 2297-1769



TÍTULO: Intrapancreatic accessory spleens in African swine fever infection of wild boar (Sus scrofa)


REVISTA: Front Vet Sci


NUMERACIÓN: 10:1306320


AÑO: 2023


EDITORIAL: Lausanne : Frontiers Media S.A


AUTORES: Porras N., Chinchilla-Rodríguez B., Rodriguez-Bertos A., Barasona JA., Kosowska A., Vazquez-Fernandez E., Sanchez-Cordon PJ. and Sanchez-Vizcaino JM..


First
Néstor Porras González
2nd
Blanca Chinchilla Rodríguez
3rd
Antonio Manuel Rodríguez Bertos
4th
José Ángel Barasona García-Arévalo
5th
Aleksandra Kosowska
Last
José Manuel Sánchez-Vizcaíno Rodríguez

DOI: https://doi.org/10.3389/fvets.2023.1306320


CITA ESTA PUBLICACIÓN:

Porras N., Chinchilla-Rodríguez B., Rodriguez-Bertos A., Barasona JA., Kosowska A., Vazquez-Fernandez E., Sanchez-Cordon PJ. y Sanchez-Vizcaino JM. Intrapancreatic accessory spleens in African swine fever infection of wild boar (Sus scrofa). Frontiers in veterinary science. 10:1306320. 2023. (A). ISSN: 2297-1769. DOI: 10.3389/fvets.2023.1306320


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