Repeated oral dosing with Listeria monocytogenes in mice as a model of central nervous system listeriosis in man
Artículo de investigación publicado en Journal of Comparative Pathology
1 de julio de 1999
Human1999 W.B. Saunders Company Ltdlisteriosis is a food-borne disease of immunosuppressed or previously healthy adults. The repeated oral administration of a sublethal dose (5×109colony-forming units) ofCopyright Listeria monocytogenesfor 7 or 10 consecutive days led to the development of severe central nervous system (CNS) lesions in 25% of experimental mice. Histopathological examination of the brain revealed rhombencephalitis and ventriculitis as two distinct inflammatory patterns, resembling those seen in human listeriosis. This model would seem to be potentially useful for research on pathogenesis, predisposing factors and therapy in CNS listeriosis in man.1999 W.B. Saunders and Company Ltd.
Altimira J., Prats N., Lopez S., Domingo M., Briones V., Dominguez L. y Marco A.
 | Departamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM). |
| Servicio de Identificación y Caracterización Microbiana (ICM). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM). |
 | Departamento de Patología y Producciones Animales. Facultad de Veterinaria. Universitat Autònoma de Barcelona (UAB). |
