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Strength of association between isolation of Pasteurella multocida and consolidation lesions in ovine pneumonic pasteurellosis

Investigación publicada en Veterinary Microbiology

In Press

This study investigated the association of Pasteurella multocida isolation and the molecular characteristics of the isolates with the presence of pneumonic lesions in lambs at slaughter to assess its importance as a causative agent of pneumonic pasteurellosis compared with Mannheimia haemolytica. P. multocida was isolated from the 13.9% and 2.7%, and M. haemolytica from the 36.4% and 26.8%, of lungs with and without lesions, respectively (P < 0.05). Both microorganisms were frequently coisolated (23.2% and 12.5% from lungs with and without lesions, respectively). Isolation of P. multocida alone exhibited greater strength of association with pneumonic lesions (OR 11.4; 95% CI 3.2–40.6) than that exhibited by M. haemolytica alone (OR 3.0; 95% CI 1.6–5.4). Cluster analysis grouped the lungs into four clusters characterized by the isolation of M. haemolytica or P. multocida alone (clusters 1 and 4), coisolation of both microorganisms (cluster 3), and isolation of neither (cluster 2). Cluster 4 lungs exhibited higher frequencies of pneumonic lesions (87.5%) and severe (20.8%) and moderate (25.0%) lesions. Lungs coinfected with both pathogens (cluster 3) did not exhibit a higher frequency of severe and moderate consolidation lesions (6.1% and 14.3%, respectively), suggesting that P. multocida and M. haemolytica do not act synergically to cause more severe pneumonic infections. The greater strength of association of P. multocida isolation with pneumonic lesions together with the higher severity of the lesions caused could indicate a greater role played by this pathogen in the aetiopathogenesis of pneumonic pasteurellosis in sheep than is commonly assumed




Cid D., Pinto C., Dominguez L., Vela AI. y Fernandez-Garayzabal JF..




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Strength of association between isolation of Pasteurella multocida and consolidation lesions in ovine pneumonic pasteurellosis

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Strength of association between isolation of Pasteurella multocida and consolidation lesions in ovine pneumonic pasteurellosis


Participantes:

Universidad ComplutenseDepartamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).

Universidad ComplutenseServicio de Identificación y Caracterización Microbiana (ICM). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

University College LondonLondon School of Hygiene and Tropical Medicine (LSHTM). University College London (UCL).







Veterinary Microbiology
FACTOR YEAR Q
3.030 2019

NLMID: 7705469

PMID: 32891951

ISSN: 0378-1135



TÍTULO: Strength of association between isolation of Pasteurella multocida and consolidation lesions in ovine pneumonic pasteurellosis


REVISTA: Vet. Microbiol.


EDITORIAL: Elsevier Science Publishers


AUTORES: Cid D., Pinto C., Dominguez L., Vela AI. and Fernandez-Garayzabal JF..


PARTICIPANTES VISAVET


3rd
Lucas Domínguez Rodríguez
4th
Ana Isabel Vela Alonso
Last
José Francisco Fernández-Garayzabal Fernández

DOI: https://doi.org/10.1016/j.vetmic.2020.108823


CITA ESTA PUBLICACIÓN:

Cid D., Pinto C., Dominguez L., Vela AI. y Fernandez-Garayzabal JF. Strength of association between isolation of Pasteurella multocida and consolidation lesions in ovine pneumonic pasteurellosis. Veterinary Microbiology. In Press. (A). ISSN: 0378-1135. DOI: 10.1016/j.vetmic.2020.108823


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