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The Role of Interleukine-10 and Interferon-gamma as Potential Markers of the Evolution of African Swine Fever Virus Infection in Wild Boar

Investigación publicada en Pathogens

15 de junio de 2021

African swine fever virus (ASFv) is one of the most challenging pathogens to affect both domestic and wild pigs. The disease has now spread to Europe and Asia, causing great damage to the pig industry. Although no commercial vaccine with which to control the disease is, as yet, available, some potential vaccine candidates have shown good results in terms of protection. However, little is known about the host immune mechanisms underlying that protection, especially in wild boar, which is the main reservoir of the disease in Europe. Here, we study the role played by two cytokines (IL-10 and IFN-γ) in wild boar orally inoculated with the attenuated vaccine candidate Lv17/WB/Rie1 and challenged with a virulent ASFv genotype II isolate. A group of naïve wild boar challenged with the latter isolate was also established as a control group. Our results showed that both cytokines play a key role in protecting the host against the challenge virus. While high levels of IL-10 in serum may trigger an immune system malfunctioning in challenged animals, the provision of stable levels of this cytokine over time may help to control the disease. This, together with high and timely induction of IFN-γ by the vaccine candidate, could help protect animals from fatal outcomes. Further studies should be conducted in order to support these preliminary results and confirm the role of these two cytokines as potential markers of the evolution of ASFV infection




Barroso-Arevalo S., Barasona JA., Cadenas-Fernández E. y Sanchez-Vizcaino JM..




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The Role of Interleukine-10 and Interferon-gamma as Potential Markers of the Evolution of African Swine Fever Virus Infection in Wild Boar

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The Role of Interleukine-10 and Interferon-gamma as Potential Markers of the Evolution of African Swine Fever Virus Infection in Wild Boar


Participantes:

Universidad ComplutenseServicio de Inmunología Viral y Medicina Preventiva (SUAT). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).

Universidad ComplutenseDepartamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).







Pathogens
FACTOR YEAR Q
3.492 2020

NLMID: 101596317

PMID: 34203976

ISSN: 2076-0817



TÍTULO: The Role of Interleukine-10 and Interferon-gamma as Potential Markers of the Evolution of African Swine Fever Virus Infection in Wild Boar


REVISTA: Pathogens


NUMERACIÓN: 10(6):757


AÑO: 2021


EDITORIAL: MDPI


AUTORES: Barroso-Arevalo S., Barasona JA., Cadenas-Fernández E. and Sanchez-Vizcaino JM..


PARTICIPANTES VISAVET


First
Sandra Barroso Arévalo
2nd
José Ángel Barasona García-Arévalo
3rd
Estefanía Cadenas Fernández
Last
José Manuel Sánchez-Vizcaíno Rodríguez

DOI: https://doi.org/10.3390/pathogens10060757


CITA ESTA PUBLICACIÓN:

Barroso-Arevalo S., Barasona JA., Cadenas-Fernández E. y Sanchez-Vizcaino JM. The Role of Interleukine-10 and Interferon-gamma as Potential Markers of the Evolution of African Swine Fever Virus Infection in Wild Boar. Pathogens. 10(6):757. 2021. (A). ISSN: 2076-0817. DOI: 10.3390/pathogens10060757


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