Artículo de investigación publicado en International Journal of Medical Microbiology

1 de diciembre de 2013

Clonal variants of Mycobacterium tuberculosis can emerge as a result of microevolution phenomena. The functional significance of these subtle genetic rearrangements is normally disregarded. We show that clonal variants from two patients had different infective behaviours in some in vitro cellular infection models but not in others. Microevolution may have a subtle impact on infectivity, but specific experimental conditions are needed to unmask it

Navarro Y., Perez-Lago L., Sislema F., Herranz M., de Juan L., Bouza E. y Garcia de Viedma D.

Unmasking subtle differences in the infectivity of microevolved Mycobacterium tuberculosis variants coinfecting the same patient

Unmasking subtle differences in the infectivity of microevolved Mycobacterium tuberculosis variants coinfecting the same patient

	Servicio de Micobacterias (MYC). Centro de Vigilancia Sanitaria Veterinaria (VISAVET). Universidad Complutense (UCM).
	Departamento de Sanidad Animal. Facultad de Veterinaria. Universidad Complutense (UCM).
	CEI Campus Moncloa.
	Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES). Instituto de Salud Carlos III (ISCIII).
	Facultad de Medicina. Universidad Complutense (UCM).
	Instituto de Investigación Sanitaria Gregorio Marañón (IISGM). Servicio de Microbiología y Enfermedades Infecciosas. Hospital General Universitario Gregorio Marañón. Consejería de Sanidad. Comunidad de Madrid.