WildTBVac

WP leader: R. Juste (NEIKER)

Objectives:

• To provide resources for effective coordination of all project activities and maintenance of contact with Commission representatives.
• To implement an administration and communication infrastructure to establish a basis for efficient and easy communication within the project.
• To effectively monitor the project, in administrative and financial terms.
• To guarantee the adherence of the work to the overall project plans, available resources and planning.
• To undertake quality assessment of project progress, results and impact.
• To ensure that the required reporting is prepared and delivered in a timely manner.
• To ensure that the Description of Work and the Consortium Agreement are maintained and updated where and when necessary.
• Overall legal, contractual, ethical, financial and administrative management of the project.

Tasks:

• Task 1.1 Project Management Plan and Quality Plan
• Task 1.2 Management Coordination
• Task 1.3 Technical and Financial Reporting

WP leader: R. Juste (NEIKER)

Objectives:

• To produce a bank of strains seeds from a selected isolate of M. bovis
• To standardize the medium-large scale production of the selected vaccine strain in terms of shortest time, maximum amount and optimal and stable genetic and antigenic features.
• To demonstrate that DIVA reagents developed in VLA to distinguish BCG vaccination from M. bovis infection can also be applied to this prime-boost scenario
• To standardize the composition of the vaccine product according to the route of administration in terms of dose and adjuvants for maximal protection and minimal diagnostic interference.
• Analysis of commercial aspects for technology transfer.

Tasks:

• Task 2.1 Equipment set-up
• Task 2.2 Large scale mycobacterial growth
• Task 2.3 Definition of optimal production conditions
• Task 2.4 Stability of vaccine batches
• Task 2.5 Final optimal formulation

WP leader: M. Vordermeier (DEFRA)

Objectives:

• To validate vaccine-associated diagnostic strategies that will allow the differentiation of ‘accidentally’ vaccinated domestic animals from their infected counterparts.

Tasks:

• Task 3.1 Tuberculin skin test and IGRA reactivity
• Task 3.2 Antigenically defined skin test and IGRA reactivity
• Task 3.3 Serological tests in pigs
• Task 3.4 Multi-species serological assay

WP leader: C. Gortázar (UCLM).

Objective:

• To assess efficacy of oral vaccination alone.
• To assess efficacy of selective culling alone.
• To assess efficacy of the two combined strategies, selective culling + vaccination.

Tasks:

• Task 4.1 Controlled field assessment of oral vaccination in wild boar
• Task 4.2 Test and cull strategies in wild boar captured under field conditions
• Task 4.3 Assessment of the combined effect of previous tasks

WP leader: P. Pasquali (ISS)

Objectives:

• To assess the efficacy of such vaccine to protect domestic and feral pigs in such endemic area of tuberculosis.

Tasks:

• Task 5.1 Assessment of immune status of vaccinated piglets.
• Task 5.2 M. bovis and corresponding lesions assessment.

WP leader: L. de Juan (UCM).

WP leader: F. Bastida (VACUNEK).

Objectives:

• To guarantee the adherence of the work to the overall project plans, available resources and planning.
• To undertake quality assessment of project progress, results and impact.
• To ensure that the required reporting is prepared and delivered in a timely manner.

Tasks:

• Task 6.1 Dissemination activities.
• Task 6.2 Exploitation, business models and technology transfer.
• Task 6.3 Market, legislation and investment plan.
• Task 6.4 Scientific Coordination