wildtbvac.eu


FP7-KBBE-2013-613799


Integrated solutions for tuberculosis
control in animals combining vaccination
and multi-species diagnostics

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WildTBVac

Organisation image
Work Package 1. Management and coordination.


WP leader: R. Juste (NEIKER)

Objectives:

  • To provide resources for effective coordination of all project activities and maintenance of contact with Commission representatives.
  • To implement an administration and communication infrastructure to establish a basis for efficient and easy communication within the project.
  • To effectively monitor the project, in administrative and financial terms.
  • To guarantee the adherence of the work to the overall project plans, available resources and planning.
  • To undertake quality assessment of project progress, results and impact.
  • To ensure that the required reporting is prepared and delivered in a timely manner.
  • To ensure that the Description of Work and the Consortium Agreement are maintained and updated where and when necessary.
  • Overall legal, contractual, ethical, financial and administrative management of the project.

Tasks:

  • Task 1.1 Project Management Plan and Quality Plan
  • Task 1.2 Management Coordination
  • Task 1.3 Technical and Financial Reporting


Work Package 2. Vaccine optimization and scale-up.


WP leader: R. Juste (NEIKER)

Objectives:

  • To produce a bank of strains seeds from a selected isolate of M. bovis
  • To standardize the medium-large scale production of the selected vaccine strain in terms of shortest time, maximum amount and optimal and stable genetic and antigenic features.
  • To demonstrate that DIVA reagents developed in VLA to distinguish BCG vaccination from M. bovis infection can also be applied to this prime-boost scenario
  • To standardize the composition of the vaccine product according to the route of administration in terms of dose and adjuvants for maximal protection and minimal diagnostic interference.
  • Analysis of commercial aspects for technology transfer.

Tasks:

  • Task 2.1 Equipment set-up
  • Task 2.2 Large scale mycobacterial growth
  • Task 2.3 Definition of optimal production conditions
  • Task 2.4 Stability of vaccine batches
  • Task 2.5 Final optimal formulation


Work Package 3. Evaluation of vaccine-associated diagnostic strategies including use of defined diagnostic antigens.


WP leader: M. Vordermeier (DEFRA)

Objectives:

  • To validate vaccine-associated diagnostic strategies that will allow the differentiation of ‘accidentally’ vaccinated domestic animals from their infected counterparts.

Tasks:

  • Task 3.1 Tuberculin skin test and IGRA reactivity
  • Task 3.2 Antigenically defined skin test and IGRA reactivity
  • Task 3.3 Serological tests in pigs
  • Task 3.4 Multi-species serological assay


Work Package 4. Integrated field TB control in wild boar.


WP leader: C. Gortázar (UCLM).

Objective:

  • To assess efficacy of oral vaccination alone.
  • To assess efficacy of selective culling alone.
  • To assess efficacy of the two combined strategies, selective culling + vaccination.

Tasks:

  • Task 4.1 Controlled field assessment of oral vaccination in wild boar
  • Task 4.2 Test and cull strategies in wild boar captured under field conditions
  • Task 4.3 Assessment of the combined effect of previous tasks


Work Package 5. Evaluation of efficacy of heat-inactivated M. bovis as oral vaccine in domestic and feral pigs.


WP leader: P. Pasquali (ISS)

Objectives:

  • To assess the efficacy of such vaccine to protect domestic and feral pigs in such endemic area of tuberculosis.

Tasks:

  • Task 5.1 Assessment of immune status of vaccinated piglets.
  • Task 5.2 M. bovis and corresponding lesions assessment.


Work Package 6. Dissemination, exploitation, market preparation and scientific coordination.


WP leader: L. de Juan (UCM).

WP leader: F. Bastida (VACUNEK).

Objectives:

  • To guarantee the adherence of the work to the overall project plans, available resources and planning.
  • To undertake quality assessment of project progress, results and impact.
  • To ensure that the required reporting is prepared and delivered in a timely manner.

Tasks:

  • Task 6.1 Dissemination activities.
  • Task 6.2 Exploitation, business models and technology transfer.
  • Task 6.3 Market, legislation and investment plan.
  • Task 6.4 Scientific Coordination

Organisation

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